Understanding the Photochemical Pathway of In Vitro Target Delivery of Aluminium Phthalocyanine: A Mechanistic Approach Using Radical Reaction ChemistryVise andre og tillknytning
2014 (engelsk)Inngår i: ChemPlusChem, E-ISSN 2192-6506, Vol. 79, nr 5, s. 671-679Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]
A classical dye, aluminium phthalocyanine (AlPc), is used to study the photochemical processes involved in the chromophore-assisted laser inactivation technique. Both cell-free and cell-based systems are investigated by novel methods and radical reaction chemistry. Findings on the photochemical pathways in two models representing cell-free and a cell-based systems are reported. In the cell-free system, the unsubstituted, free, fluorescence-active photosensitiser AlPc recovers its fluorescence signal by means of phosphorescence through a reversible photobleaching process. In the cell-based system, photoactivation of substituted AlPc conjugated to an antibody results in the loss of fluorescence signal at the area examined. Reinjection of the AlPc-conjugated antibodies restores the fluorescence signal.
sted, utgiver, år, opplag, sider
2014. Vol. 79, nr 5, s. 671-679
Emneord [en]
cleavage reactions, fluorescence, photochemistry, phthalocyanines, radicals
HSV kategori
Identifikatorer
URN: urn:nbn:se:kth:diva-147048DOI: 10.1002/cplu.201300402ISI: 000335515800005Scopus ID: 2-s2.0-84900405079OAI: oai:DiVA.org:kth-147048DiVA, id: diva2:728328
Merknad
QC 20140624
2014-06-242014-06-232022-06-23bibliografisk kontrollert