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Readily Available Ruthenium Complex for Efficient Dynamic Kinetic Resolution of Aromatic alpha-Hydroxy Ketones
Stockholm University, Faculty of Science, Department of Organic Chemistry.
Stockholm University, Faculty of Science, Department of Organic Chemistry.
Stockholm University, Faculty of Science, Department of Organic Chemistry.
Stockholm University, Faculty of Science, Department of Organic Chemistry.ORCID iD: 0000-0002-7898-317X
2014 (English)In: Organic Letters, ISSN 1523-7060, E-ISSN 1523-7052, Vol. 16, no 8, p. 2256-2259Article in journal (Refereed) Published
Abstract [en]

A ruthenium complex formed from commercially available [Ru(p-cymene)Cl-2](2) and 1,4-bis(diphenylphosphino)butane catalyzes the racemization of aromatic alpha-hydroxy ketones very efficiently at room temperature. The racemization is fully compatible with a kinetic resolution catalyzed by a lipase from Pseudomonas stutzeri. This is the first example of dynamic kinetic resolution of alpha-hydroxy ketones at ambient temperature in which the metal and enzyme catalysts work in concert in one pot at room temperature to give quantitative yields of esters of alpha-hydroxy ketones with very high enantioselectivity.

Place, publisher, year, edition, pages
2014. Vol. 16, no 8, p. 2256-2259
National Category
Organic Chemistry
Identifiers
URN: urn:nbn:se:su:diva-104150DOI: 10.1021/ol500764qISI: 000334823600047OAI: oai:DiVA.org:su-104150DiVA, id: diva2:722636
Note

AuthorCount:4;

Available from: 2014-06-09 Created: 2014-06-03 Last updated: 2018-04-05Bibliographically approved

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Agrawal, SantoshMartínez-Castro, ElisaMartín-Matute, Belén
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