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A Chromosome-Centric Analysis of Antibodies Directed toward the Human Proteome Using Antibodypedia
KTH, Centra, Science for Life Laboratory, SciLifeLab.ORCID-id: 0000-0002-2643-8241
KTH, Centra, Science for Life Laboratory, SciLifeLab.ORCID-id: 0000-0002-0257-7554
KTH, Centra, Science for Life Laboratory, SciLifeLab.ORCID-id: 0000-0001-7034-0850
KTH, Centra, Science for Life Laboratory, SciLifeLab.ORCID-id: 0000-0001-8800-8469
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2014 (Engelska)Ingår i: Journal of Proteome Research, ISSN 1535-3893, E-ISSN 1535-3907, Vol. 13, nr 3, s. 1669-1676Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

Antibodies are crucial for the study of human proteins and have been defined as one of the three pillars in the human chromosome-centric Human Proteome Project (CHPP). In this article the chromosome-centric structure has been used to analyze the availability of antibodies as judged by the presence within the portal Antibodypedia, a database designed to allow comparisons and scoring of publicly available antibodies toward human protein targets. This public database displays antibody data from more than one million antibodies toward human protein targets. A summary of the content in this knowledge resource reveals that there exist more than 10 antibodies to over 70% of all the putative human genes, evenly distributed over the 24 human chromosomes. The analysis also shows that at present, less than 10% of the putative human protein-coding genes (n = 1882) predicted from the genome sequence lack antibodies, suggesting that focused efforts from the antibody-based and mass spectrometry-based proteomic communities should be encouraged to pursue the analysis of these missing proteins. We show that Antibodypedia may be used to track the development of available and validated antibodies to the individual chromosomes, and thus the database is an attractive tool to identify proteins with no or few antibodies yet generated.

Ort, förlag, år, upplaga, sidor
2014. Vol. 13, nr 3, s. 1669-1676
Nyckelord [en]
Human proteome, Affinity reagents, Antibodies, Antibodypedia
Nationell ämneskategori
Biokemi och molekylärbiologi
Identifikatorer
URN: urn:nbn:se:kth:diva-144382DOI: 10.1021/pr4011525ISI: 000332756300045PubMedID: 24533432Scopus ID: 2-s2.0-84896795822OAI: oai:DiVA.org:kth-144382DiVA, id: diva2:713226
Forskningsfinansiär
Science for Life Laboratory - a national resource center for high-throughput molecular bioscienceKnut och Alice Wallenbergs Stiftelse
Anmärkning

QC 20140422

Tillgänglig från: 2014-04-22 Skapad: 2014-04-22 Senast uppdaterad: 2024-03-15Bibliografiskt granskad

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Av författaren/redaktören
Alm, Tovevon Feilitzen, KalleLundberg, EmmaSivertsson, ÅsaUhlén, Mathias
Av organisationen
Science for Life Laboratory, SciLifeLabProteomik och nanobioteknologi
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Journal of Proteome Research
Biokemi och molekylärbiologi

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