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Antibiotic resistance among Escherichia coli isolates from stool samples of children aged 3 to 14 years from Ujjain, India
Department of Microbiology, R.D. Gardi Medical College, Ujjain, India.
Global Health (IHCAR), Department of Public Health Sciences, Karolinska Institutet, Stockholm, Sweden.
Global Health (IHCAR), Department of Public Health Sciences, Karolinska Institutet, Stockholm, Sweden.
Department of Microbiology, R.D. Gardi Medical College, Ujjain, India.
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2013 (Engelska)Ingår i: BMC Infectious Diseases, ISSN 1471-2334, E-ISSN 1471-2334, Vol. 13, s. 477-Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

Background: Antibiotic resistance is a major global public health concern, particularly in settings where few treatment options are available. Limited research has been done on antibiotic resistance in Escherichia coli of Indian children at community level. Therefore we studied antibiotic resistance patterns in E. coli isolates from stool samples of children aged 3-14 years from Ujjain, Central India, to investigate associations of resistance with demographic variables. Methods: Children, 3-14 years of age, were included from 30 randomly selected villages of Palwa demographic surveillance site, Ujjain, India. Parents were interviewed using a questionnaire, and stool samples were collected from participating children. E. coli were isolated from stool samples (n = 529), and susceptibility testing to 18 different antibiotics was done using standard methods. Results: The proportions of isolates resistant to various antibiotics were, nalidixic acid, (45%), tetracycline (37%), ampicillin (37%), sulfamethoxazole/trimethoprim (29%) and amoxicillin/clavulanic acid (29%). No isolates were resistant to imipenem. Overall, 72% of isolates were resistant to at least one antibiotic and 33% were multi-drug resistant. High rates of cross-resistance were seen for 15 (83%) of the antibiotics studied. E. coli isolates from children with literate mothers were more resistant to penicillins and fluoroquinolones. ESBL-producers comprised 9% of the isolates. Conclusion: Antibiotic resistance and cross-resistance were common in E. coli from stools of children. Resistance rates were associated with maternal literacy.

Ort, förlag, år, upplaga, sidor
2013. Vol. 13, s. 477-
Nyckelord [en]
E. coli, Faecal, Children, Commensal, Antibiotic resistance, Asia
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Medicin och hälsovetenskap
Identifikatorer
URN: urn:nbn:se:uu:diva-215955DOI: 10.1186/1471-2334-13-477ISI: 000328900900001OAI: oai:DiVA.org:uu-215955DiVA, id: diva2:688785
Tillgänglig från: 2014-01-17 Skapad: 2014-01-17 Senast uppdaterad: 2017-12-06Bibliografiskt granskad

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Pathak, Ashish
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