Positron emission tomography is a powerful imaging method capable of diagnosing and studyingdiseases at atomic levels. The following thesis involves the synthesis of a 2 -deoxy-2 -[18F]uoro-D-glucose derivative able to participate in click chemisty conjugation. The synthesis involves six stepswith D-mannopyranose as starting material; regioselective acetylation and protection of the hydroxylgroup on C-2 of the monosaccharide, glycosylation with 2-azidoethanol, removal of the selectiveprotecting group and substitution of the hydroxyl group on C-2 with uorine. The potential toconjugate the glycoside to other biomolecules and obtain PET data might have uses in diagnosticaland medicinal chemistry.