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Screening and determination of drugs in human saliva utilizing microextraction by packed sorbent and liquid chromatography-tandem mass spectrometry
Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för analytisk kemi.
Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för analytisk kemi.ORCID-id: 0000-0002-3862-8878
2013 (engelsk)Inngår i: BMC Biomedical chromotography, ISSN 0269-3879, E-ISSN 1099-0801, Vol. 27, nr 9, s. 1188-1191Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

This study presents a new method for collecting and handling saliva samples using an automated analytical microsyringe and microextraction by packed syringe (MEPS). The screening and determination of lidocaine in human saliva samples utilizing MEPS and liquid chromatography-tandem mass spectrometry (LC-MS/MS) were carried out. An exact volume of saliva could be collected. The MEPS C-8-cartridge could be used for 50 extractions before it was discarded. The extraction recovery was about 60%. The pharmacokinetic curve of lidocaine in saliva using MEPS-LC-MS/MS is reported.

sted, utgiver, år, opplag, sider
2013. Vol. 27, nr 9, s. 1188-1191
Emneord [en]
eVol, MEPS, LC-MS/MS, lidocaine, saliva samples
HSV kategori
Identifikatorer
URN: urn:nbn:se:su:diva-93554DOI: 10.1002/bmc.2925ISI: 000322717100015OAI: oai:DiVA.org:su-93554DiVA, id: diva2:647717
Merknad

AuthorCount:2;

Tilgjengelig fra: 2013-09-12 Laget: 2013-09-10 Sist oppdatert: 2019-12-09bibliografisk kontrollert

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Abdel Rehim, Mohamed
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