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Association of the European lactase persistence variant (LCT-13910 C > T Polymorphism) with obesity in the Canary Islands
Örebro universitet, Institutionen för hälsovetenskap och medicin.
Preventive Medicine Service, Canary Health Service, Department of Clinical Sciences, Faculty of Health Sciences, University of Las Palmas de Gran Canaria, Las Palmas, Spain.
Preventive Medicine Service, Canary Health Service, Department of Clinical Sciences, Faculty of Health Sciences, University of Las Palmas de Gran Canaria, Las Palmas, Spain.
2012 (engelsk)Inngår i: PLoS ONE, ISSN 1932-6203, E-ISSN 1932-6203, Vol. 7, nr 8, artikkel-id e43978Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

Background: European lactose tolerance genotype (LCT -13910 C>T, rs4988234) has been positively associated to body mass indexes (BMI) in a meta-analysis of 31,720 individuals of northern and central European descent. A strong association of lactase persistence (LP) with BMI and obesity has also been traced in a Spanish Mediterranean population. The aim of this study was to analyze a potential association of LP compared to lactase non-persistence (LNP) with BMI in inhabitants of the Canary Islands of Spain using Mendelian randomization.

Methods: A representative, randomly sampled population of adults belonging to the Canary Islands Nutrition Survey (ENCA) in Spain, aged 18-75 years (n = 551), was genotyped for the LCT - 13910 C>T polymorphism. Milk consumption was assessed by a validated questionnaire. Anthropometric variables were directly measured. WHO classification of BMI was used.

Results: LP individuals were significantly more obese than LNP subjects (chi(2) = 10.59; p < 0.005). LP showed in a multivariate linear regression analysis showed a positive association of LP with BMI compared to LNP, (beta = 0.96; 95% CI: 0.08-1.85, p = 0.033). In a multinomial logistic regression analysis normal range weight LP subjects showed an odds ratio for obesity of 2.41; 95% CI 1.39-418, (p = 0.002) compared to LNP.

Conclusions: The T-13910 of the allele LCT-13910 C>T polymorphism is positively associated with BMI. LP increases significantly the risk to develop obesity in the studied population. The LCT-13910 C>T polymorphism stands proxy for the lifetime exposure pattern, milk intake, that may increase susceptibility to obesity and to obesity related pathologies.

sted, utgiver, år, opplag, sider
San Francisco: Public Library Science , 2012. Vol. 7, nr 8, artikkel-id e43978
HSV kategori
Forskningsprogram
Medicin
Identifikatorer
URN: urn:nbn:se:oru:diva-29769DOI: 10.1371/journal.pone.0043978ISI: 000308225500131PubMedID: 22937140Scopus ID: 2-s2.0-84866601832OAI: oai:DiVA.org:oru-29769DiVA, id: diva2:633645
Tilgjengelig fra: 2013-06-27 Laget: 2013-06-25 Sist oppdatert: 2018-08-27bibliografisk kontrollert

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