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Electronystagmographic findings in rats exposed to styrene or toluene
Linköpings universitet.
Linköpings universitet.
Linköpings universitet.
Linköpings universitet.
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1982 (Engelska)Ingår i: Acta Oto-Laryngologica, ISSN 0001-6489, E-ISSN 1651-2251, Vol. 93, s. 107-112Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

A previously described experimental model for studying the effect of industrial solvents in the vestibular system of rabbits has been applied to rats. To achieve a constant concentration, the solvent was infused intravenously, dissolved in a lipid emulsion. Arterial blood levels were estimated by gas chromatography. The vestibulo-oculomotor behaviour of rats during repeated rotatory acceleration was investigated by electronystagmography. The effect of two solvents-toluene and styrene-on the rotatory induced nystagmus was examined. Both solvents caused an exaggerated reaction at arterial blood  levels above 75 ppm. The investigation indicated that the rat will be suitable species for further electronystagmographic investigation of the influence of organic solvents on the vestibular system, for example in screening studies of the toxicity of these solvents.

Ort, förlag, år, upplaga, sidor
1982. Vol. 93, s. 107-112
Nationell ämneskategori
Medicin och hälsovetenskap
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URN: urn:nbn:se:liu:diva-91747PubMedID: 6977982OAI: oai:DiVA.org:liu-91747DiVA, id: diva2:619001
Tillgänglig från: 2013-05-01 Skapad: 2013-05-01 Senast uppdaterad: 2017-12-06Bibliografiskt granskad

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Tham, RichardLarsby, BirgittaÖdkvist, Lars
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Linköpings universitetÖstergötlands Läns Landsting
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