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Current status on plasma biomarkers for acute mesenteric ischemia
Vascular Center, Skåne University Hospital, Malmö, Sweden.
Department of Clinical Chemistry, Örebro University Hospital, Örebro, Sweden.
2012 (English)In: Journal of Thrombosis and Thrombolysis, ISSN 0929-5305, E-ISSN 1573-742X, Vol. 33, no 4, p. 355-361Article in journal (Refereed) Published
Abstract [en]

Clinical diagnosis of acute mesenteric ischemia is difficult. The aim of this review is to provide current status on the search for an accurate plasma biomarker for acute mesenteric ischemia. A search using the medical subject heading terms marker and mesenteric ischemia or intestinal ischemia or superior mesenteric artery occlusion or mesenteric venous thrombosis in the Medline and Embase databases from 1980 to 2011. Studies without a control group or a control group consisted of healthy individuals (human studies), or studies on intestinal reperfusion were excluded. Twenty animal and twelve human studies were identified. In human studies, the studied series of patients had a control group that had a need of laparotomy (n = 2), suspected acute mesenteric ischemia (n = 7), acute abdomen (n = 2) or systemic inflammatory response syndrome (n = 1). D: -dimer has been found to be the most consistent highly sensitive early marker, but specificity was low. The follow-up study on α-glutathione S-transferase yielded inferior sensitivity and accuracy than the preliminary study, clearly questioning the value of this marker. Intestinal fatty acid binding globulin (I-FABP) and D: -lactate are both interesting markers, but the results were conflicting. Different cut-off levels have been used in the studies on I-FABP. The encouraging preliminary result of cobalt-albumin and urinary FABP as an accurate marker needs to be addressed in other study populations. The early clinical and laboratory diagnosis of intestinal ischemia remains a challenge. None of the proposed plasma-derived tests for acute mesenteric ischemia has as yet entered routine clinical practice. The proposed biomarkers need to be evaluated in a prospective clinical research project in patients with acute abdomen.

Place, publisher, year, edition, pages
Springer, 2012. Vol. 33, no 4, p. 355-361
Keywords [en]
Acute mesenteric ischemia; Plasma markers
National Category
Hematology Cardiac and Cardiovascular Systems
Research subject
Cardiology
Identifiers
URN: urn:nbn:se:oru:diva-27904DOI: 10.1007/s11239-011-0660-zISI: 000303508600009PubMedID: 22081293Scopus ID: 2-s2.0-84865197785OAI: oai:DiVA.org:oru-27904DiVA, id: diva2:610724
Available from: 2013-03-12 Created: 2013-03-12 Last updated: 2017-12-06Bibliographically approved

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