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Human cardiovascular dose-response to supplemental oxygen
Vise andre og tillknytning
2007 (engelsk)Inngår i: Acta Physiologica, ISSN 1748-1708, E-ISSN 1748-1716, Vol. 191, nr 1, s. 15-24Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

AIM: The aim of the study was to examine the central and peripheral cardiovascular adaptation and its coupling during increasing levels of hyperoxaemia. We hypothesized a dose-related effect of hyperoxaemia on left ventricular performance and the vascular properties of the arterial tree.

METHODS: Oscillometrically calibrated arterial subclavian pulse trace data were combined with echocardiographic recordings to obtain non-invasive estimates of left ventricular volumes, aortic root pressure and flow data. For complementary vascular parameters and control purposes whole-body impedance cardiography was applied. In nine (seven males) supine, resting healthy volunteers, aged 23-48 years, data was collected after 15 min of air breathing and at increasing transcutaneous oxygen tensions (20, 40 and 60 kPa), accomplished by a two group, random order and blinded hyperoxemic protocol.

RESULTS: Left ventricular stroke volume [86 +/- 13 to 75 +/- 9 mL (mean +/- SD)] and end-diastolic area (19.3 +/- 4.4 to 16.8 +/- 4.3 cm(2)) declined (P < 0.05), and showed a linear, negative dose-response relationship to increasing arterial oxygen levels in a regression model. Peripheral resistance and characteristic impedance increased in a similar manner. Heart rate, left ventricular fractional area change, end-systolic area, mean arterial pressure, arterial compliance or carbon dioxide levels did not change.

CONCLUSION: There is a linear dose-response relationship between arterial oxygen and cardiovascular parameters when the systemic oxygen tension increases above normal. A direct effect of supplemental oxygen on the vessels may therefore not be excluded. Proximal aortic and peripheral resistance increases from hyperoxaemia, but a decrease of venous return implies extra cardiac blood-pooling and compensatory relaxation of the capacitance vessels.

sted, utgiver, år, opplag, sider
2007. Vol. 191, nr 1, s. 15-24
Emneord [en]
arterial compliance, end-diastolic area, hyperoxaemia, hyperoxia, normocapnia, stroke volume, vascular resistance
HSV kategori
Identifikatorer
URN: urn:nbn:se:kth:diva-85770DOI: 10.1111/j.1748-1716.2007.01710.xISI: 000248593900002PubMedID: 17506865Scopus ID: 2-s2.0-34547651215OAI: oai:DiVA.org:kth-85770DiVA, id: diva2:500095
Merknad
QC 20120301Tilgjengelig fra: 2012-02-13 Laget: 2012-02-13 Sist oppdatert: 2020-05-11bibliografisk kontrollert

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Janerot-Sjöberg, Birgitta
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