Endre søk
RefereraExporteraLink to record
Permanent link

Direct link
Referera
Referensformat
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Annet format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annet språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf
Evolution of four gene families with patchy phylogenetic distributions: influx of genes into protist genomes
Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Biologiska sektionen, Institutionen för cell- och molekylärbiologi.
2006 (engelsk)Inngår i: BMC Evolutionary Biology, ISSN 1471-2148, E-ISSN 1471-2148, Vol. 6, artikkel-id 27Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

BACKGROUND: Lateral gene transfer (LGT) in eukaryotes from non-organellar sources is a controversial subject in need of further study. Here we present gene distribution and phylogenetic analyses of the genes encoding the hybrid-cluster protein, A-type flavoprotein, glucosamine-6-phosphate isomerase, and alcohol dehydrogenase E. These four genes have a limited distribution among sequenced prokaryotic and eukaryotic genomes and were previously implicated in gene transfer events affecting eukaryotes. If our previous contention that these genes were introduced by LGT independently into the diplomonad and Entamoeba lineages were true, we expect that the number of putative transfers and the phylogenetic signal supporting LGT should be stable or increase, rather than decrease, when novel eukaryotic and prokaryotic homologs are added to the analyses. RESULTS: The addition of homologs from phagotrophic protists, including several Entamoeba species, the pelobiont Mastigamoeba balamuthi, and the parabasalid Trichomonas vaginalis, and a large quantity of sequences from genome projects resulted in an apparent increase in the number of putative transfer events affecting all three domains of life. Some of the eukaryotic transfers affect a wide range of protists, such as three divergent lineages of Amoebozoa, represented by Entamoeba, Mastigamoeba, and Dictyostelium, while other transfers only affect a limited diversity, for example only the Entamoeba lineage. These observations are consistent with a model where these genes have been introduced into protist genomes independently from various sources over a long evolutionary time. CONCLUSION: Phylogenetic analyses of the updated datasets using more sophisticated phylogenetic methods, in combination with the gene distribution analyses, strengthened, rather than weakened, the support for LGT as an important mechanism affecting the evolution of these gene families. Thus, gene transfer seems to be an on-going evolutionary mechanism by which genes are spread between unrelated lineages of all three domains of life, further indicating the importance of LGT from non-organellar sources into eukaryotic genomes.

sted, utgiver, år, opplag, sider
2006. Vol. 6, artikkel-id 27
Emneord [en]
Alcohol Dehydrogenase/genetics, Aldehyde Oxidoreductases/genetics, Aldose-Ketose Isomerases/genetics, Animals, Bacterial Proteins/genetics, Biodiversity, DNA; Protozoan/chemistry, Ecology, Entamoeba/classification/genetics, Evolution, Feeding Behavior/physiology, Gene Transfer; Horizontal/*genetics, Iron-Sulfur Proteins/genetics, Markov Chains, Molecular Sequence Data, Monte Carlo Method, Multienzyme Complexes/genetics, NADH; NADPH Oxidoreductases/genetics, Naegleria/classification/genetics, Phylogeny, Polymerase Chain Reaction/methods, Protozoa/classification/*genetics, Trichomonas vaginalis/classification/genetics
HSV kategori
Identifikatorer
URN: urn:nbn:se:uu:diva-21912DOI: 10.1186/1471-2148/6/27ISI: 000238824300001PubMedID: 16551352OAI: oai:DiVA.org:uu-21912DiVA, id: diva2:49685
Tilgjengelig fra: 2007-01-08 Laget: 2007-01-08 Sist oppdatert: 2017-12-07bibliografisk kontrollert

Open Access i DiVA

fulltext(529 kB)162 nedlastinger
Filinformasjon
Fil FULLTEXT01.pdfFilstørrelse 529 kBChecksum SHA-512
5c9f4b48982cde1f076e70444ce838c03d08059215cbfa29e2d7d420e9d1e55d2a4eb2617b13969a0889bb00008d63f1a1542775eb3f674caa72804a1610c912
Type fulltextMimetype application/pdf

Andre lenker

Forlagets fulltekstPubMed

Søk i DiVA

Av forfatter/redaktør
Andersson, Jan O.
Av organisasjonen
I samme tidsskrift
BMC Evolutionary Biology

Søk utenfor DiVA

GoogleGoogle Scholar
Totalt: 162 nedlastinger
Antall nedlastinger er summen av alle nedlastinger av alle fulltekster. Det kan for eksempel være tidligere versjoner som er ikke lenger tilgjengelige

doi
pubmed
urn-nbn

Altmetric

doi
pubmed
urn-nbn
Totalt: 984 treff
RefereraExporteraLink to record
Permanent link

Direct link
Referera
Referensformat
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Annet format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annet språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf