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Normal levels of constitutive and death receptor-mediated apoptosis of peripheral blood neutrophils from patients with chronic idiopathic neutropenia.
Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper. (Inflammation)
2007 (Engelska)Ingår i: Clinical Immunology, ISSN 1521-6616, E-ISSN 1521-7035, Vol. 122, nr 3, s. 349-355Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

To investigate the role of neutrophil apoptosis in the pathogenesis of chronic neutropenia, we examined constitutive and death receptor-mediated apoptosis ex vivo of peripheral blood neutrophils obtained from six chronic idiopathic neutropenia (CIN) patients and six healthy adult blood donors. Apoptosis was quantified based on phosphatidylserine externalization and caspase-3 activation in freshly isolated neutrophils or after overnight cultivation of neutrophils in the absence or presence of pro- or anti-apoptotic factors, including the pan-caspase inhibitor, zVAD-fmk. Neutrophils from CIN patients receiving treatment with granulocyte colony-stimulating factor appeared to be more prone to constitutive apoptosis than cells from untreated patients; however, further investigations in larger cohorts of patients are needed to validate these pilot studies. Overall, the level of neutrophil apoptosis was similar in patient and control groups, thus supporting the notion that the underlying defect in these neutropenia patients lies elsewhere, such as in the bone marrow microenvironment.

Ort, förlag, år, upplaga, sidor
2007. Vol. 122, nr 3, s. 349-355
Nyckelord [en]
Adult, Aged; 80 and over, Apoptosis/*immunology, Cells; Cultured, Chronic Disease, Female, Humans, Male, Middle Aged, Neutropenia/immunology/metabolism/*pathology, Neutrophils/immunology/*metabolism/*pathology, Receptors; Death Domain/blood/*physiology
Nationell ämneskategori
Medicin och hälsovetenskap
Identifikatorer
URN: urn:nbn:se:uu:diva-17299DOI: 10.1016/j.clim.2006.10.015PubMedID: 17188576OAI: oai:DiVA.org:uu-17299DiVA, id: diva2:45070
Anmärkning
Publikation från annat universitetTillgänglig från: 2008-06-18 Skapad: 2008-06-18 Senast uppdaterad: 2017-12-08Bibliografiskt granskad

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Förlagets fulltextPubMedhttp://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Retrieve&list_uids=17188576&dopt=Citation

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