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DaTSCAN SPECT EVALUATION OF PATIENTS WITH MOVEMENT DISORDERS
Linköpings universitet, Institutionen för medicin och hälsa, Avdelningen för radiologiska vetenskaper. Linköpings universitet, Medicinska fakulteten. Region Östergötland, Diagnostikcentrum, Röntgenkliniken i Linköping.
Linköpings universitet, Institutionen för medicin och hälsa, Klinisk fysiologi. Linköpings universitet, Hälsouniversitetet. Östergötlands Läns Landsting, Hjärt- och Medicincentrum, Fysiologiska kliniken US.
Linköpings universitet, Institutionen för medicin och hälsa, Klinisk fysiologi. Linköpings universitet, Hälsouniversitetet. Östergötlands Läns Landsting, Hjärt- och Medicincentrum, Fysiologiska kliniken US.
Östergötlands Läns Landsting, Diagnostikcentrum, Klinisk kemi.
Vise andre og tillknytning
2011 (engelsk)Inngår i: EUROPEAN JOURNAL OF NEUROLOGY, Wiley-Blackwell, 2011, Vol. 18 (Suppl. 2), nr SI, s. 567-567, artikkel-id P2617Konferansepaper, Poster (with or without abstract) (Annet vitenskapelig)
Abstract [en]

Introduction: Molecular imaging with DaTSCAN SPECTis widely used as a diagnostic tool in patients with movementdisorders in the form of Parkinson's Disease (PD),Parkinson-plus syndromes and Tremor. In the present studythe potency of DATScan SPECT to detect degeneration inthe basal ganglia in early stages of PD, before the onset ofmedication, is evaluated. In addition the efficacy ofDaTSCAN for differential diagnosis between patients withidiopathic PD and patients with Parkinson-plus syndromesis examined.

Methodology: Participants: 21 patients with PD in earlystages, before the onset of medication, 20 patients withidiopathic PD and 6 patients with Parkinson-plussyndromes. 15 participants with normal results ofDaTSCAN SPECT and a clinical diagnosis different fromPD or Parkinson-plus were used as control.

DaTSCAN SPECT: In the present study the quantificationof Striatum Occipital/Occipital and the Xeleris workstation(GE) were used.

Results: The quantification for patients with idiopathic PD(1.185±0.05687) was significantly lower (p<0.0001) fromthe control (2.369±0.1258) and significantly lower (p<0.05)from that of patients in early stages of PD, before the onsetof medication (1.359±0.05324). There was no significantdifference between the idiopathic PD and Parkinson-plussyndromes (1.103±0.2442).

Conclusion: DaTSCAN SPECT can detect efficiently earlydegeneration in the basal ganglia before the onset ofmedication is needed. Its efficacy for the differentialdiagnosis between idiopathic PD and Parkinson-plussyndromes is questioned. The combination of imaging andclinical examination is mandatory for a certain diagnosis.

sted, utgiver, år, opplag, sider
Wiley-Blackwell, 2011. Vol. 18 (Suppl. 2), nr SI, s. 567-567, artikkel-id P2617
Serie
European Journal of Neurology, ISSN 1351-5101, E-ISSN 1468-1331
HSV kategori
Identifikatorer
URN: urn:nbn:se:liu:diva-71081DOI: 10.1111/j.1468-1331.2011.03552.xISI: 000294806601394OAI: oai:DiVA.org:liu-71081DiVA, id: diva2:444857
Konferanse
15th Congress of the European-Federation-of-Neurological-Societies (EFNS), Budapest, Hungary, September 10-13, 2011
Tilgjengelig fra: 2011-09-30 Laget: 2011-09-30 Sist oppdatert: 2018-01-12bibliografisk kontrollert

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