Ändra sökning
RefereraExporteraLänk till posten
Permanent länk

Direktlänk
Referera
Referensformat
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Annat format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annat språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf
Genetic Variants in Toll-Like Receptors Are Not Associated with Rheumatoid Arthritis Susceptibility or Anti-Tumour Necrosis Factor Treatment Outcome
Radboud University Nijmegen.
University of Copenhagen Hospital.
Radboud University Nijmegen.
Radboud University Nijmegen.
Visa övriga samt affilieringar
2010 (Engelska)Ingår i: PLOS ONE, ISSN 1932-6203, Vol. 5, nr 12Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

Background: Several studies point to a role of Toll-like receptors (TLRs) in the development of rheumatoid arthritis (RA). We investigated if genetic variants in TLR genes are associated with RA and response to tumour necrosis factor blocking (anti-TNF) medication. Methodology and Principal Findings: 22 single nucleotide polymorphisms (SNPs) in seven TLR genes were genotyped in a Dutch cohort consisting of 378 RA patients and 294 controls. Significantly associated variants were investigated in replication cohorts from The Netherlands, United Kingdom and Sweden (2877 RA patients and 2025 controls). 182 of the Dutch patients were treated with anti-TNF medication. Using these patients and a replication cohort (269 Swedish patients) we analysed if genetic variants in TLR genes were associated with anti-TNF outcome. In the discovery phase of the study we found a significant association of SNPs rs2072493 in TLR5 and rs3853839 in TLR7 with RA disease susceptibility. Meta-analysis of discovery and replication cohorts did not confirm these findings. SNP rs2072493 in TLR5 was associated with anti-TNF outcome in the Dutch but not in the Swedish population. Conclusion: We conclude that genetic variants in TLRs do not play a major role in susceptibility for developing RA nor in anti-TNF treatment outcome in a Caucasian population.

Ort, förlag, år, upplaga, sidor
Public Library of Science (PLoS) , 2010. Vol. 5, nr 12
Nationell ämneskategori
Medicin och hälsovetenskap
Identifikatorer
URN: urn:nbn:se:liu:diva-64236DOI: 10.1371/journal.pone.0014326ISI: 000285340000005OAI: oai:DiVA.org:liu-64236DiVA, id: diva2:388404
Anmärkning
Original Publication: Marieke J H Coenen, Christian Enevold, Pilar Barrera, Mascha M V A P Schijvenaars, Erik J M Toonen, Hans Scheffer, Leonid Padyukov, Alf Kastbom, Lars Klareskog, Anne Barton, Wietske Kievit, Tim L Jansen, Dorine Swinkels, Piet L C M van Riel, Barbara Franke, Klaus Bendtzen and Timothy R D J Radstake, Genetic Variants in Toll-Like Receptors Are Not Associated with Rheumatoid Arthritis Susceptibility or Anti-Tumour Necrosis Factor Treatment Outcome, 2010, PLOS ONE, (5), 12. http://dx.doi.org/10.1371/journal.pone.0014326 Licensee: Public Library of Science (PLoS) http://www.plos.org/ Tillgänglig från: 2011-01-17 Skapad: 2011-01-17 Senast uppdaterad: 2011-02-17

Open Access i DiVA

fulltext(558 kB)184 nedladdningar
Filinformation
Filnamn FULLTEXT01.pdfFilstorlek 558 kBChecksumma SHA-512
b3f28aaed0d9ed753b88af87e567de007dc0e0ccc786e64865a04da40d98763f0dd866c51fac051b0cda5398f99a73b6f10ac5d669076ba25b2d7a373b9304dd
Typ fulltextMimetyp application/pdf

Övriga länkar

Förlagets fulltext

Sök vidare i DiVA

Av författaren/redaktören
Kastbom, Alf
Av organisationen
ReumatologiHälsouniversitetetLänskliniken för Reumatologi i Östergötland
Medicin och hälsovetenskap

Sök vidare utanför DiVA

GoogleGoogle Scholar
Totalt: 184 nedladdningar
Antalet nedladdningar är summan av nedladdningar för alla fulltexter. Det kan inkludera t.ex tidigare versioner som nu inte längre är tillgängliga.

doi
urn-nbn

Altmetricpoäng

doi
urn-nbn
Totalt: 343 träffar
RefereraExporteraLänk till posten
Permanent länk

Direktlänk
Referera
Referensformat
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Annat format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annat språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf