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Thyroid-stimulating hormone receptor and thyroid hormone receptors are involved in human endometrial physiology
Dept of Clinical Science, Karolinska Institutet, Stockholm, Sweden.
Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för kvinnors och barns hälsa. (Klinisk och experimentell reproduktionsbiologi/Olovsson)
Dept of Clinical Science, Karolinska Institutet, Stockholm, Sweden.
Dept of Clinical Science, Karolinska Institutet, Stockholm, Sweden.
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2011 (Engelska)Ingår i: Fertility and Sterility, ISSN 0015-0282, E-ISSN 1556-5653, Vol. 95, nr 1, s. 230-237Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

OBJECTIVE: To study the expression, distribution, and function of thyroid-stimulating hormone receptor (TSHR) and thyroid hormone receptors (TR) alpha1, alpha2, and beta1 in human endometrium. DESIGN: Experimental clinical study. SETTING: University hospital. PATIENT(S): 31 fertile women. INTERVENTION(S): Endometrial biopsy samples obtained throughout the menstrual cycle. MAIN OUTCOME MEASURE(S): Real-time reverse transcriptase polymerase chain reaction, immunohistochemistry and Western blot to study the expression of TSHR, TRalpha1, TRalpha2, and TRbeta1 messenger RNA (mRNA) and proteins in human endometrium. RESULT(S): We found TSHR, TRalpha1, TRalpha2 and TRbeta1 mRNA and proteins expressed in human endometrium. Immunostaining for TSHR in the luminal epithelium and TRalpha1 and beta1 in the glandular and luminal epithelium increased statistically significantly on luteinizing hormone (LH) days 6 to 9, coinciding with appearance of pinopodes. Endometrial stromal and Ishikawa cells expressed mRNA for TSHR, TR, and iodothyronine deiodinases 1-3. After 48 hours, TSH significantly increased leukemia inhibitory factor (LIF) and LIF receptor (LIFR) messenger RNA (mRNA) in endometrial stromal cells, but decreased their expression in Ishikawa cells. Glucose transporter 1 mRNA was up-regulated by TSH in Ishikawa cells. We found that TSH statistically significantly increased secretion of free triiodothyronine (T(3)) and total thyroxin (T(4)) by Ishikawa cells compared with nonstimulated cells. CONCLUSION(S): Thyroid hormones are directly involved in endometrial physiology.

Ort, förlag, år, upplaga, sidor
2011. Vol. 95, nr 1, s. 230-237
Nyckelord [en]
Deiodinases, human endometrium, thyroid hormone receptor, thyroid hormones, TSH receptor
Nationell ämneskategori
Medicin och hälsovetenskap
Identifikatorer
URN: urn:nbn:se:uu:diva-129373DOI: 10.1016/j.fertnstert.2010.06.079ISI: 000285411600047PubMedID: 20691434OAI: oai:DiVA.org:uu-129373DiVA, id: diva2:343175
Tillgänglig från: 2010-08-12 Skapad: 2010-08-12 Senast uppdaterad: 2017-12-12Bibliografiskt granskad

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