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Influence of tissue movements on laser Doppler perfusion imaging
Linköpings universitet, Institutionen för medicinsk teknik, Biomedicinsk instrumentteknik. Linköpings universitet, Tekniska högskolan.
Linköpings universitet, Institutionen för medicinsk teknik, Biomedicinsk instrumentteknik. Linköpings universitet, Tekniska högskolan.ORCID-id: 0000-0001-6385-6760
Linköpings universitet, Institutionen för medicinsk teknik, Biomedicinsk instrumentteknik. Linköpings universitet, Tekniska högskolan.
Linköpings universitet, Institutionen för medicinsk teknik, Biomedicinsk instrumentteknik. Linköpings universitet, Tekniska högskolan.ORCID-id: 0000-0002-0012-7867
2002 (Engelska)Ingår i: Proceedings of SPIE Volume 4624: Optical Diagnostics and Sensing of Biological Fluids and Glucose and Cholesterol Monitoring II / [ed] Alexander V. Priezzhev; Gerard L. Cote, SPIE - International Society for Optical Engineering, 2002, Vol. 4624, s. 106-114Konferensbidrag, Publicerat paper (Övrigt vetenskapligt)
Abstract [en]

The microvascular perfusion can be measured using laser Doppler blood flowmetry (LDF), a technique sensitive to the concentration of moving blood cells and their velocity. However, movements of the tissue itself can cause artifacts in the perfusion readings. In a clinical situation, these movement induced artifacts may arise from patient movements or from movements of internal organs e.g. the intestines or the beating heart. Therefore, we have studied how a well-controlled tissue movement affects the LDF signals during different flow conditions and for different surface structures. Tissue perfusion was recorded non-touch in one point using a laser Doppler perfusion imager. During the measurements the object was placed on a shaker that generated the movement (both horizontal and vertical). Measurements were carried out both on DELRIN« (polyacetal plastic) and the fingertip, for a wide range of velocities (0-3 cm/s). The influence of the microvascular perfusion was evaluated by occluding the brachial artery as well as blood emptying the finger and by using a flow model. The LDF signals were correlated to the movement. In vivo measurements showed that velocities above 0.8 cm/s gave a significant contribution to the perfusion signal. Corresponding velocities for the DELRIN« piece were higher (1.4 - 2.6 cm/s), and dependent on the surface structures and reflecting properties. By reducing the amount of specular reflection the movement influence was substantially lowered.

Ort, förlag, år, upplaga, sidor
SPIE - International Society for Optical Engineering, 2002. Vol. 4624, s. 106-114
Serie
Progress in Biomedical Optics and Imaging, ISSN 1605-7422
Nationell ämneskategori
Medicinsk laboratorie- och mätteknik
Identifikatorer
URN: urn:nbn:se:liu:diva-24552DOI: 10.1117/12.468313ISI: 000176856000013Lokalt ID: 6712ISBN: 0819443638 (tryckt)ISBN: 9780819443632 (tryckt)OAI: oai:DiVA.org:liu-24552DiVA, id: diva2:244873
Konferens
Optical Diagnostics and Sensing of Biological Fluids and Glucose and Cholesterol Monitoring II, San Jose, CA, USA January 19, 2002
Tillgänglig från: 2009-10-07 Skapad: 2009-10-07 Senast uppdaterad: 2016-09-01Bibliografiskt granskad

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Karlsson, Daniel M GLarsson, MarcusStrömberg, TomasWårdell, Karin
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Biomedicinsk instrumentteknikTekniska högskolan
Medicinsk laboratorie- och mätteknik

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