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Standardized volume rendering for magnetic resonance angiography measurements in the abdominal aorta
Linköpings universitet, Centrum för medicinsk bildvetenskap och visualisering, CMIV. Linköpings universitet, Institutionen för medicin och hälsa, Medicinsk radiologi. Linköpings universitet, Hälsouniversitetet. Östergötlands Läns Landsting, Bildmedicinskt centrum, Röntgenkliniken i Linköping.ORCID-id: 0000-0002-9446-6981
Karolinska Institutet, CLINTEC, Röntgenavdelningen, Karolinska Universitetssjukhuset Huddinge.
Linköpings universitet, Institutionen för teknik och naturvetenskap, Visuell informationsteknologi och applikationer. Linköpings universitet, Tekniska högskolan. Linköpings universitet, Centrum för medicinsk bildvetenskap och visualisering, CMIV.ORCID-id: 0000-0002-9368-0177
Linköpings universitet, Centrum för medicinsk bildvetenskap och visualisering, CMIV. Linköpings universitet, Institutionen för medicin och hälsa, Medicinsk radiologi. Linköpings universitet, Hälsouniversitetet. Östergötlands Läns Landsting, Bildmedicinskt centrum, Röntgenkliniken i Linköping.ORCID-id: 0000-0002-4111-1693
Vise andre og tillknytning
2006 (engelsk)Inngår i: Acta Radiologica, ISSN 0284-1851, E-ISSN 1600-0455, Vol. 47, nr 2, s. 172-178Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

Purpose: To compare three methods for standardizing volume rendering technique (VRT) protocols by studying aortic diameter measurements in magnetic resonance angiography (MRA) datasets.

Material and Methods: Datasets from 20 patients previously examined with gadolinium-enhanced MRA and with digital subtraction angiography (DSA) for abdominal aortic aneurysm were retrospectively evaluated by three independent readers. The MRA datasets were viewed using VRT with three different standardized transfer functions: the percentile method (Pc-VRT), the maximum-likelihood method (ML-VRT), and the partial range histogram method (PRH-VRT). The aortic diameters obtained with these three methods were compared with freely chosen VRT parameters (F-VRT) and with maximum intensity projection (MIP) concerning inter-reader variability and agreement with the reference method DSA.

Results: F-VRT parameters and PRH-VRT gave significantly higher diameter values than DSA, whereas Pc-VRT gave significantly lower values than DSA. The highest interobserver variability was found for F-VRT parameters and MIP, and the lowest for Pc-VRT and PRH-VRT. All standardized VRT methods were significantly superior to both MIP and F-VRT in this respect. The agreement with DSA was best for PRH-VRT, which was the only method with a mean error below 1 mm and which also had the narrowest limits of agreement (95% of cases between 2.1 mm below and 3.1 mm above DSA).

Conclusion: All the standardized VRT methods compare favorably with MIP and VRT with freely selected parameters as regards interobserver variability. The partial range histogram method, although systematically overestimating vessel diameters, gives results closest to those of DSA.

sted, utgiver, år, opplag, sider
2006. Vol. 47, nr 2, s. 172-178
Emneord [en]
Abdominal aortic aneurysm (AAA); angiography; magnetic resonance angiography (MRA); maximum intensity projection (MIP); volume rendering technique (VRT); user dependence
HSV kategori
Identifikatorer
URN: urn:nbn:se:liu:diva-14591DOI: 10.1080/02841850500445298ISI: 000236669500010OAI: oai:DiVA.org:liu-14591DiVA, id: diva2:23978
Tilgjengelig fra: 2007-08-24 Laget: 2007-08-24 Sist oppdatert: 2017-12-13bibliografisk kontrollert
Inngår i avhandling
1. Efficient Medical Volume Visualization: An Approach Based on Domain Knowledge
Åpne denne publikasjonen i ny fane eller vindu >>Efficient Medical Volume Visualization: An Approach Based on Domain Knowledge
2007 (engelsk)Doktoravhandling, med artikler (Annet vitenskapelig)
Abstract [en]

Direct Volume Rendering (DVR) is a visualization technique that has proved to be a very powerful tool in many scientific visualization applications. Diagnostic medical imaging is one domain where DVR could provide clear benefits in terms of unprecedented possibilities for analysis of complex cases and highly efficient work flow for certain routine examinations. The full potential of DVR in the clinical environment has not been reached, however, primarily due to limitations in conventional DVR methods and tools.

This thesis presents methods addressing four major challenges for DVR in clinical use. The foundation of all methods is to incorporate the domain knowledge of the medical professional in the technical solutions. The first challenge is the very large data sets routinely produced in medical imaging today. To this end a multiresolution DVR pipeline is proposed, which dynamically prioritizes data according to the actual impact in the rendered image to be reviewed. Using this prioritization the system can reduce the data requirements throughout the pipeline and provide high performance and visual quality in any environment.

Another problem addressed is how to achieve simple yet powerful interactive tissue classification in DVR. The methods presented define additional attributes that effectively captures readily available medical knowledge. The task of tissue detection is also important to solve in order to improve efficiency and consistency of diagnostic image review. Histogram-based techniques that exploit spatial relations in the data to achieve accurate and robust tissue detection are presented in this thesis.

The final challenge is uncertainty visualization, which is very pertinent in clinical work for patient safety reasons. An animation method has been developed that automatically conveys feasible alternative renderings. The basis of this method is a probabilistic interpretation of the visualization parameters.

Several clinically relevant evaluations of the developed techniques have been performed demonstrating their usefulness. Although there is a clear focus on DVR and medical imaging, most of the methods provide similar benefits also for other visualization techniques and application domains.

sted, utgiver, år, opplag, sider
Institutionen för teknik och naturvetenskap, 2007. s. 55
Serie
Linköping Studies in Science and Technology. Dissertations, ISSN 0345-7524 ; 1125
Emneord
Scientific Visualization, Medical Imaging, Computer Graphics, Volume Rendering, Transfer Function, Level-of-detail, Fuzzy Classification, Uncertainty Visualization, Virtual Autopsies
HSV kategori
Identifikatorer
urn:nbn:se:liu:diva-9561 (URN)978-91-85831-10-4 (ISBN)
Disputas
2007-09-14, Berzeliussalen, Hälsouniversitetet, Linköping, 13:15 (engelsk)
Opponent
Veileder
Tilgjengelig fra: 2007-08-24 Laget: 2007-08-24 Sist oppdatert: 2015-09-22
2. Volume imaging of the abdomen: three-dimensional visualisation of tubular structures in the body with CT and MRI
Åpne denne publikasjonen i ny fane eller vindu >>Volume imaging of the abdomen: three-dimensional visualisation of tubular structures in the body with CT and MRI
2005 (engelsk)Doktoravhandling, med artikler (Annet vitenskapelig)
Abstract [en]

The overwhelming amount of image-based information in modem medicine makes it crucial to develop methods to handle and analyze images and make them comprehensible for users. The aim of this thesis was to study the radiological practice of three-dimensional (3D) visualization of tubular structures in the body with CT and MRI. All the studies cancern 3D imaging of tubular structures with camputed tomography (CT) and magnetic resonance imaging (MRI). The first three studies examine the abdominal aorta; the two later ones the, bile ducts.

Study I compared measurements of aorta diameters taken from MR images presented using two visualization methods - maximum intensity projection (MlP) and volume rendering (VRT) - with invasive angiography (DSA) and CT as reference methods. Mean diameters of MR images were smaller than those from DSA and CT when MlP was used, but in general not when VRT was used.

Study II evaluated the dependence on the observer and the choice of method and settings during rendering using the same material as in Study 1. In both MlP and VRT, the choice of settings had significant influence on the results. With DSA as the reference method, VRT gave larger measurement errors than MIP when the rendering parameters were set to fixed values, but not if the user was allowed to select the settings freely.

Study III evaluated three new techniques for standardizing VRT protocols for MRA. Inter-reader variability and agreement with DSA were studied by comparing diameter measurements of the abdominal aorta obtained by the three new techniques, by VRT with freely chosen parameters and by MlP. All three new methods were significantly better than MlP and VRT with freely chosen parameters conceming inter-observer agreement. Agreement with DSA was significantly better for one of the methods. Standardized protocols seem to have a potential to make VRT a clinically useful alternative to MlP for MR angiography measurements.

Study IV evaluated CT imaging of the bile ducts after drip intravenous infusion of the contrast medium iotroxate (CT cholangiography) in terms of adverse effects and visibility. With infusion time adjusted for individual variation in serum bilirubin concentration, a total side-effect frequency of less than 1% was found. A systematic review of previously published studies indicated a frequency of 2.3%. Good contrast excretion and visualization of bile ducts even in patients with elevated bilirubin levels were noted.

Study V evaluated the diagnostic benefits of the same imaging method by comparing it with findings from surgery and endoscopic retrograde cholangiopancreatography (ERCP). The consensus sensitivity and specificity for diagnosing biliary stones was 88% and 94%, respectively. The use of VRT improved diagnostic certainty in 14% of the evaluatians, and the visualization of ductal stones was improved in 38% of the positive cases.

In conclusion, volume rendering technique with standardized parameters may become a clinically useful tool in the clinical MRI environment. DIC-CT with bilirubin-governed infusion time and volume rendering post-processing produces detailed images of the biliary tree, resulting in good sensitivity and specificity. Moreover the safety is acceptable.

sted, utgiver, år, opplag, sider
Linköping: Linköpings universitet, 2005. s. 103
Serie
Linköping University Medical Dissertations, ISSN 0345-0082 ; 912
HSV kategori
Identifikatorer
urn:nbn:se:liu:diva-29581 (URN)14957 (Lokal ID)91-85299-25-1 (ISBN)14957 (Arkivnummer)14957 (OAI)
Disputas
2005-10-07, Berzeliussalen, plan 09, Hälsouniversitetet, Campus US, Linköpings universitet, Linköping, 13:00 (svensk)
Opponent
Veileder
Tilgjengelig fra: 2009-10-09 Laget: 2009-10-09 Sist oppdatert: 2013-10-21bibliografisk kontrollert

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