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Automated radiosynthesis of [18F]CETO, a PET radiotracer for imaging adrenal glands, on Synthra RNplus
Univ Cambridge, Wolfson Brain Imaging Ctr, Dept Clin Neurosci, Mol Imaging Chem Lab, Cambridge, England.;Univ Cambridge, Sch Clin Med, Dept Clin Neurosci, Wolfson Brain Imaging Ctr,Radiopharmaceut Unit, Cambridge Biomed Campus, Cambridge CB2 0QQ, England..ORCID-id: 0000-0002-0814-6894
Univ Cambridge, Wolfson Brain Imaging Ctr, Sch Clin Med, Dept Clin Neurosci,Radiopharmaceut Unit, Cambridge, England..
Univ Cambridge, Wolfson Brain Imaging Ctr, Sch Clin Med, Dept Clin Neurosci,Radiopharmaceut Unit, Cambridge, England..
Univ Cambridge, Wolfson Brain Imaging Ctr, Sch Clin Med, Dept Clin Neurosci,Radiopharmaceut Unit, Cambridge, England..
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2024 (engelsk)Inngår i: Journal of labelled compounds & radiopharmaceuticals, ISSN 0362-4803, E-ISSN 1099-1344, Vol. 67, nr 2, s. 67-75Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

Primary aldosteronism (PA) is the leading secondary cause of hypertension. Determining whether one (unilateral) or both (bilateral) adrenal glands are the source of PA in a patient remains challenging, and yet it is a critical step in the decision whether to recommend potentially curative surgery (adrenalectomy) or lifelong medical therapy (typically requiring multiple drugs). Recently, we have developed a fluorine-18 radiopharmaceutical [(18) F]CETO to permit greater access to PA molecular imaging. Herein, we report an automated synthesis of this radiotracer. To manufacture the radiopharmaceutical routinely for clinical PET studies, we implemented an automated radiosynthesis method on a Synthra RNplus (c) synthesiser for which Cl-tosyletomidate was used as the precursor for radiolabelling via nucleophilic [(18) F]fluorination. [(18) F]CETO was produced with 35 +/- 1% (n = 7), decay corrected and 25 +/- 4% (n = 7) non-decay corrected radiochemical yield with molar activities ranging from 150 to 400 GBq/mu mol. The GMP compliant manufacturing process produces a sterile formulated [(18) F]CETO injectable solution for human use as demonstrated by the results of quality control. Automation of the radiosynthesis of [(18) F]CETO should facilitate uptake by other adrenal centres and increase access to molecular imaging in PA.

sted, utgiver, år, opplag, sider
John Wiley & Sons, 2024. Vol. 67, nr 2, s. 67-75
Emneord [en]
[F-18]CETO, adrenal, fluorine-18 radiosynthesis, PET imaging, primary aldosteronism, Synthra RNplus
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Identifikatorer
URN: urn:nbn:se:uu:diva-533248DOI: 10.1002/jlcr.4078ISI: 001128059300001PubMedID: 38116667OAI: oai:DiVA.org:uu-533248DiVA, id: diva2:1880361
Tilgjengelig fra: 2024-07-01 Laget: 2024-07-01 Sist oppdatert: 2024-07-01bibliografisk kontrollert

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