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Triple network model of brain connectivity changes related to adverse mood effects in an oral contraceptive placebo-controlled trial
Univ Salzburg, Dept Psychol, Salzburg, Austria.;Univ Salzburg, Ctr Cognit Neurosci, Salzburg, Austria.;Univ Michigan, Dept Psychol, Ann Arbor, MI 48109 USA.;Univ Michigan, Chron Pain & Fatigue Res Ctr, Dept Anesthesiol, Ann Arbor, MI 48109 USA..
Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Psychology.ORCID iD: 0000-0002-3648-3652
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Women's and Children's Health, Reproductive Health. Uppsala University, WoMHeR (Centre for Women’s Mental Health during the Reproductive Lifespan).ORCID iD: 0000-0002-2491-2042
Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Psychology. Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Women's and Children's Health, Reproductive Health. Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Psychiatry.ORCID iD: 0000-0001-5310-6843
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2023 (English)In: Translational Psychiatry, E-ISSN 2158-3188, Vol. 13, no 1, article id 209Article in journal (Refereed) Published
Abstract [en]

Combined oral contraceptives (COC) are among the most commonly used contraceptive methods worldwide, and mood side effects are the major reason for discontinuation of treatment. We here investigate the directed connectivity patterns associated with the mood side effects of an androgenic COC in a double-blind randomized, placebo-controlled trial in women with a history of affective COC side effects (n = 34). We used spectral dynamic causal modeling on a triple network model consisting of the default mode network (DMN), salience network (SN) and executive control network (ECN). Within this framework, we assessed the treatment-related changes in directed connectivity associated with adverse mood side effects. Overall, during COC use, we found a pattern of enhanced connectivity within the DMN and decreased connectivity within the ECN. The dorsal anterior cingulate cortex (SN) mediates an increased recruitment of the DMN by the ECN during treatment. Mood lability was the most prominent COC-induced symptom and also arose as the side effect most consistently related to connectivity changes. Connections that were related to increased mood lability showed increased connectivity during COC treatment, while connections that were related to decreased mood lability showed decreased connectivity during COC treatment. Among these, the connections with the highest effect size could also predict the participants' treatment group above chance.

Place, publisher, year, edition, pages
Springer Nature, 2023. Vol. 13, no 1, article id 209
National Category
Neurosciences
Identifiers
URN: urn:nbn:se:uu:diva-507448DOI: 10.1038/s41398-023-02470-xISI: 001010082700002PubMedID: 37328507OAI: oai:DiVA.org:uu-507448DiVA, id: diva2:1781140
Funder
Swedish Research Council, K200854X-200642013Forte, Swedish Research Council for Health, Working Life and Welfare, 20071955Forte, Swedish Research Council for Health, Working Life and Welfare, 20072116EU, European Research Council, 850953Available from: 2023-07-07 Created: 2023-07-07 Last updated: 2024-01-17Bibliographically approved

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Engman, JonasPoromaa, Inger SundströmGingnell, Malin
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