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High prevalence of persistent symptoms and reduced health-related quality of life 6 months after COVID-19
Department of Infectious Diseases, Faculty of Medicine and Health, Örebro University, Örebro, Sweden.
Department of Surgical and Perioperative Sciences, Umeå University, Umeå, Sweden.
Department of Clinical Microbiology, Umeå University, Umeå, Sweden.
Department of Surgical and Perioperative Sciences, Umeå University, Umeå, Sweden.
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2023 (Engelska)Ingår i: Frontiers In Public Health, ISSN 2296-2565, Vol. 11, artikel-id 1104267Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

BACKGROUND: The long-term sequelae after COVID-19 constitute a challenge to public health and increased knowledge is needed. We investigated the prevalence of self-reported persistent symptoms and reduced health-related quality of life (HRQoL) in relation to functional exercise capacity, 6 months after infection, and explored risk factors for COVID-19 sequalae.

METHODS: This was a prospective, multicenter, cohort study including 434 patients. At 6 months, physical exercise capacity was assessed by a 1-minute sit-to-stand test (1MSTST) and persistent symptoms were reported and HRQoL was evaluated through the EuroQol 5-level 5-dimension (EQ-5D-5L) questionnaire. Patients with both persistent symptoms and reduced HRQoL were classified into a new definition of post-acute COVID syndrome, PACS+. Risk factors for developing persistent symptoms, reduced HRQoL and PACS+ were identified by multivariable Poisson regression.

RESULTS: Persistent symptoms were experienced by 79% of hospitalized, and 59% of non-hospitalized patients at 6 months. Hospitalized patients had a higher prevalence of self-assessed reduced overall health (28 vs. 12%) and PACS+ (31 vs. 11%). PACS+ was associated with reduced exercise capacity but not with abnormal pulse/desaturation during 1MSTST. Hospitalization was the most important independent risk factor for developing persistent symptoms, reduced overall health and PACS+.

CONCLUSION: Persistent symptoms and reduced HRQoL are common among COVID-19 survivors, but abnormal pulse and peripheral saturation during exercise could not distinguish patients with PACS+. Patients with severe infection requiring hospitalization were more likely to develop PACS+, hence these patients should be prioritized for clinical follow-up after COVID-19.

Ort, förlag, år, upplaga, sidor
Frontiers Media S.A., 2023. Vol. 11, artikel-id 1104267
Nyckelord [en]
COVID-19, EQ-5D, PACS, Post COVID-19 condition (PCC), SARS-CoV-2, long-COVID, post-acute COVID syndrome (PACS)
Nationell ämneskategori
Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi
Identifikatorer
URN: urn:nbn:se:oru:diva-104509DOI: 10.3389/fpubh.2023.1104267ISI: 000937266000001PubMedID: 36817925Scopus ID: 2-s2.0-85148359690OAI: oai:DiVA.org:oru-104509DiVA, id: diva2:1739220
Tillgänglig från: 2023-02-24 Skapad: 2023-02-24 Senast uppdaterad: 2024-01-10Bibliografiskt granskad

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Tevell, StaffanSundh, JosefinLange, AnnaCajander, Sara
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Institutionen för medicinska vetenskaperRegion Örebro län
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Frontiers In Public Health
Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi

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