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Women's Health and Drug Utilization
Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för folkhälso- och vårdvetenskap.
2007 (engelsk)Doktoravhandling, med artikler (Annet vitenskapelig)
Abstract [en]

Objectives. To study medication utilization and adherence to prescribed therapy in a female population in central Sweden. To study usage of hormone replacement therapy (HRT) in this population and to assess how HRT users compare to non-users regarding symptom reporting, general health and other variables. To evaluate symptom prevalence adjusted for potential symptom affecting variables.

Material and methods. A cross-sectional postal questionnaire study was performed in 1995 in seven counties in central Sweden. A questionnaire was sent to a random sample of 4,200 women aged 35-64, of whom 2,991 responded (71.2%). The questionnaire contained questions on psycho-socio-economic background, quality of life, self-reported health, height and weight, climacteric symptom prevalence, and menopausal status and symptoms. It also comprised questions on medication prescribed during the past year.

Results. 40% used prescribed medication and 12% took four drugs or more. Age, educational level, self-rated health, and BMI remained significantly correlated to drug use in multivariate analysis. Adherence ranged from 15%-98% depending on age, a scheduled check-up, perceived importance of medication, concern about medication, taking cardiovascular and respiratory disease drugs. The highest adherence was found for hormonal medication the lowest for musculoskeletal medication.

HRT was used by 15% of the women. 13 % used other symptom relieving therapy. HRT users reported higher score of vasomotor symptoms, except for sweating during the daytime.

Prevalence of general symptoms did not necessarily increase with age. Especially symptoms related to stress-tension-depression decreased with age. Four different symptom prevalence patterns were found.

Conclusions. Age, health status, educational level and body mass index (BMI) appear to affect drug use. Adherence to therapy is highest among elderly women who regard their medication as important and have a scheduled check-up. HRT relieves some vasomotor symptoms but does not affect other symptoms or self-rated health. Prevalence of symptoms related to Stress-tension-depression appears to decrease with age.

sted, utgiver, år, opplag, sider
Uppsala: Acta Universitatis Upsaliensis , 2007. , s. 64
Serie
Digital Comprehensive Summaries of Uppsala Dissertations from the Faculty of Medicine, ISSN 1651-6206 ; 276
Emneord [en]
women's health, epidemiology, drug utilisation, adherence, symptom prevalence, HRT
HSV kategori
Identifikatorer
URN: urn:nbn:se:uu:diva-8225ISBN: 978-91-554-6977-1 (tryckt)OAI: oai:DiVA.org:uu-8225DiVA, id: diva2:170769
Disputas
2007-10-25, Hörsalen, Ingång D1, Dag Hammarskjölds väg 17, Uppsala, Sweden, 13:15
Opponent
Veileder
Tilgjengelig fra: 2007-10-03 Laget: 2007-10-03 Sist oppdatert: 2022-03-11bibliografisk kontrollert
Delarbeid
1. Reported current use of prescription drugs and some of its determinants among 35-65-year-old women in mid-Sweden: A population-based study
Åpne denne publikasjonen i ny fane eller vindu >>Reported current use of prescription drugs and some of its determinants among 35-65-year-old women in mid-Sweden: A population-based study
2000 (engelsk)Inngår i: Journal of Clinical Epidemiology, Vol. 53, s. 647-653Artikkel i tidsskrift (Fagfellevurdert) Published
Identifikatorer
urn:nbn:se:uu:diva-96254 (URN)
Tilgjengelig fra: 2007-10-03 Laget: 2007-10-03 Sist oppdatert: 2011-08-15bibliografisk kontrollert
2. Factors associated with adherence to drug therapy: a population-based study
Åpne denne publikasjonen i ny fane eller vindu >>Factors associated with adherence to drug therapy: a population-based study
2007 (engelsk)Inngår i: European Journal of Clinical Pharmacology, ISSN 0031-6970, E-ISSN 1432-1041, Vol. 63, nr 3, s. 307-314Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

Objective  To investigate adherence to prescription in a female population aged 35–65 years.

Design  Postal questionnaire study of 2991 randomly sampled 35- to 64-year-old women in seven provinces of central Sweden. Methods  The study was performed in 1995 as a cross-sectional postal questionnaire study in seven counties in central Sweden. The questionnaire was sent to a random sample of 4200 women between the ages of 35 and 64, of whom 2991 (71.2%) responded. The questionnaire asked about drugs prescribed during the past year and about factors potentially affecting adherence. Results  The same women had different degrees of adherence to different medications. A large number of factors were associated with adherence. Multivariate analysis revealed that age, scheduled check-up, perceived importance of medication, concerns about medication safety and taking medication for a respiratory or a cardiovascular disease were significantly related to adherence. Adherence ranged from 15–98% depending on these factors, and was the lowest among young women who regarded their medication as unimportant and who had no scheduled check-up; the highest reported adherence was found among elderly women who regarded their medication as important and who had a scheduled check-up. Conclusion  Factors that were associated with the perceived importance of medication had a positive effect on adherence, while concerns about medication safety had a negative effect.

Emneord
Adherence, Communication skills, Epidemiology, Prescription, Women
HSV kategori
Identifikatorer
urn:nbn:se:uu:diva-96255 (URN)10.1007/s00228-006-0246-4 (DOI)000244091900012 ()17211620 (PubMedID)
Tilgjengelig fra: 2007-10-03 Laget: 2007-10-03 Sist oppdatert: 2017-12-14bibliografisk kontrollert
3. Hormone replacement therapy and symptom reporting in menopausal women: A population-based study of 35-65-year-old women in mid-Sweden
Åpne denne publikasjonen i ny fane eller vindu >>Hormone replacement therapy and symptom reporting in menopausal women: A population-based study of 35-65-year-old women in mid-Sweden
2002 (engelsk)Inngår i: Maturitas, Vol. 41, s. 7-15Artikkel i tidsskrift (Fagfellevurdert) Published
Identifikatorer
urn:nbn:se:uu:diva-96256 (URN)
Tilgjengelig fra: 2007-10-03 Laget: 2007-10-03 Sist oppdatert: 2011-08-15bibliografisk kontrollert
4. Age-specific symptom prevalence in women 35-64 years old: A population-based study
Åpne denne publikasjonen i ny fane eller vindu >>Age-specific symptom prevalence in women 35-64 years old: A population-based study
2009 (engelsk)Inngår i: BMC Public Health, E-ISSN 1471-2458, Vol. 9, s. 37-Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

BACKGROUND: Symptom prevalence is generally believed to increase with age. The aim of this study was to evaluate the age specific prevalence of 30 general symptoms among Swedish middle-aged women. METHODS: A cross-sectional postal questionnaire study in seven Swedish counties in a random sample of 4,200 women 35-64 years old, with 2,991 responders. Thirty general symptoms included in the Complaint Score subscale of the Gothenburg Quality of Life Instrument were used. RESULTS: Four groups of age specific prevalence patterns were identified after adjustment for the influence of educational level, perceived health and mood, body mass index, smoking habits, use of hormone replacement therapy, and use of other symptom relieving therapy. Only five symptoms (insomnia, leg pain, joint pain, eye problems and impaired hearing) increased significantly with age. Eleven symptoms (general fatigue, headache, irritability, melancholy, backache, exhaustion, feels cold, cries easily, abdominal pain, dizziness, and nausea) decreased significantly with age. Two symptoms (sweating and impaired concentration) had a biphasic course with a significant increase followed by a significant decrease. The remaining twelve symptoms (difficulty in relaxing, restlessness, overweight, coughing, breathlessness, diarrhoea, chest pain, constipation, nervousness, poor appetite, weight loss, and difficulty in urinating) had stable prevalence with age. CONCLUSION: Symptoms did not necessarily increase with age instead symptoms related to stress-tension-depression decreased.

HSV kategori
Identifikatorer
urn:nbn:se:uu:diva-96257 (URN)10.1186/1471-2458-9-37 (DOI)000264288600001 ()19171031 (PubMedID)
Tilgjengelig fra: 2007-10-03 Laget: 2007-10-03 Sist oppdatert: 2023-08-28bibliografisk kontrollert

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