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In Vivo Visualization and Quantification of Neutrophil Elastase in Lungs of COVID-19 Patients: A First-in-Humans PET Study with 11C-NES
Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Farmaceutiska fakulteten, Institutionen för läkemedelskemi, Preparativ läkemedelskemi.ORCID-id: 0000-0002-1525-5255
Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för kirurgiska vetenskaper, Radiologi.ORCID-id: 0000-0001-8324-7399
Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för kirurgiska vetenskaper, Radiologi.ORCID-id: 0000-0001-5738-9983
Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för kirurgiska vetenskaper, Radiologi.ORCID-id: 0000-0002-0384-8045
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2023 (engelsk)Inngår i: Journal of Nuclear Medicine, ISSN 0161-5505, E-ISSN 1535-5667, Vol. 64, nr 1, s. 145-148Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

COVID-19 can cause life-threatening lung-inflammation that is suggested to be mediated by neutrophils, whose effector mechanisms in COVID-19 is inexplicit. The aim of the present work is to evaluate a novel PET tracer for neutrophil elastase in COVID-19 patients and healthy controls.

METHODS: In this open-label, First-In-Man study, four patients with hypoxia due to COVID-19 and two healthy controls were investigated with positron emission tomography (PET) using the new selective and specific neutrophil elastase PET-tracer [11C]GW457427 and [15O]water for the visualization and quantification of NE and perfusion in the lungs, respectively.

RESULTS: [11C]GW457427 accumulated selectively in lung areas with ground-glass opacities on computed tomography characteristic of COVID-19 suggesting high levels on NE in these areas. In the same areas perfusion was severely reduced in comparison to healthy lung tissue as measured with [15O]water.

CONCLUSION: The data suggests that NE may be responsible for the severe lung inflammation in COVID-19 patients and that inhibition of NE could potentially reduce the acute inflammatory process and improve the condition.

sted, utgiver, år, opplag, sider
Society of Nuclear Medicine , 2023. Vol. 64, nr 1, s. 145-148
Emneord [en]
Infectious Disease, Neutrophil elastase, PET, PET/CT, Radiopharmaceuticals, [11C]GW457427
HSV kategori
Identifikatorer
URN: urn:nbn:se:uu:diva-487716DOI: 10.2967/jnumed.122.263974ISI: 001058493600007PubMedID: 35680418OAI: oai:DiVA.org:uu-487716DiVA, id: diva2:1707401
Forskningsfinansiär
Uppsala University, 1011799
Merknad

De två sista författarna delar sistaförfattarskapet

Tilgjengelig fra: 2022-10-31 Laget: 2022-10-31 Sist oppdatert: 2023-10-27bibliografisk kontrollert

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Antoni, GunnarLubberink, MarkSörensen, JensLindström, ElinElgland, MathiasEriksson, OlofHultström, MichaelFrithiof, RobertWanhainen, AndersSigfridsson, JonathanSkorup, PaulLipcsey, Miklos
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