Digitala Vetenskapliga Arkivet

Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Serotonin and dopamine transporter availability in social anxiety disorder after combined treatment with escitalopram and cognitive-behavioral therapy.
Department of Psychology, Uppsala University, Uppsala, Sweden.
Department of Psychology, Uppsala University and The Beijer Laboratory, Department of Medical Sciences, Psychiatry, Uppsala University, Uppsala, Sweden.
Department of Psychology, Uppsala University and Department of Medical Sciences, Psychiatry, Uppsala University, Uppsala, Sweden.
Department of Psychology, Uppsala University, Uppsala, Sweden.
Show others and affiliations
2022 (English)In: Translational Psychiatry, E-ISSN 2158-3188, Vol. 12, no 1, article id 436Article in journal (Refereed) Published
Abstract [en]

Selective serotonin reuptake inhibitors (SSRIs) and internet-based cognitive behavioral therapy (ICBT) are recommended treatments of social anxiety disorder (SAD), and often combined, but their effects on monoaminergic signaling are not well understood. In this multi-tracer positron emission tomography (PET) study, 24 patients with SAD were randomized to treatment with escitalopram+ICBT or placebo+ICBT under double-blind conditions. Before and after 9 weeks of treatment, patients were examined with positron emission tomography and the radioligands [11C]DASB and [11C]PE2I, probing the serotonin (SERT) and dopamine (DAT) transporter proteins respectively. Both treatment combinations resulted in significant improvement as measured by the Liebowitz Social Anxiety Scale (LSAS). At baseline, SERT-DAT co-expression was high and, in the putamen and thalamus, co-expression showed positive associations with symptom severity. SERT-DAT co-expression was also predictive of treatment success, but predictor-outcome associations differed in direction between the treatments. After treatment, average SERT occupancy in the SSRI + ICBT group was >80%, with positive associations between symptom improvement and occupancy in the nucleus accumbens, putamen and anterior cingulate cortex. Following placebo+ICBT, SERT binding increased in the raphe nuclei. DAT binding increased in both groups in limbic and striatal areas, but relations with symptom improvement differed, being negative for SSRI + ICBT and positive for placebo + ICBT. Thus, serotonin-dopamine transporter co-expression exerts influence on symptom severity and remission rate in the treatment of social anxiety disorder. However, the monoamine transporters are modulated in dissimilar ways when cognitive-behavioral treatment is given concomitantly with either SSRI-medication or pill placebo.

Place, publisher, year, edition, pages
Springer Nature , 2022. Vol. 12, no 1, article id 436
National Category
Applied Psychology
Identifiers
URN: urn:nbn:se:liu:diva-189024DOI: 10.1038/s41398-022-02187-3ISI: 000864640500001PubMedID: 36202797OAI: oai:DiVA.org:liu-189024DiVA, id: diva2:1701924
Note

Funding: Swedish Research Council; Swedish Brain Foundation; Riksbankens Jubileumsfond - the Swedish Foundation for Humanities and Social Sciences

Available from: 2022-10-07 Created: 2022-10-07 Last updated: 2024-01-17

Open Access in DiVA

fulltext(9194 kB)94 downloads
File information
File name FULLTEXT01.pdfFile size 9194 kBChecksum SHA-512
525b0ad1266a3e60cc35eb3f05a6ca80849ee47a1eeb115991b4d9004d08971cd9043147fda547c302d86ea81e53aedd8d37ce40facd1ec7afc6c36d4dcd9c59
Type fulltextMimetype application/pdf

Other links

Publisher's full textPubMed

Search in DiVA

By author/editor
Andersson, GerhardReis, Margareta
By organisation
PsychologyFaculty of Arts and SciencesDepartment of Biomedical and Clinical SciencesFaculty of Medicine and Health SciencesDivision of Clinical Chemistry and Pharmacology
In the same journal
Translational Psychiatry
Applied Psychology

Search outside of DiVA

GoogleGoogle Scholar
Total: 94 downloads
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

doi
pubmed
urn-nbn

Altmetric score

doi
pubmed
urn-nbn
Total: 151 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf