Digitala Vetenskapliga Arkivet

Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
The Role of Nuclear Medicine Imaging with F-18-FDG PET/CT, Combined In-111-WBC/(99)mTc-Nanocoll, and Tc-99m-HDP SPECT/CT in the Evaluation of Patients with Chronic Problems after TKA or THA in a Prospective Study
Aalborg Univ Hosp, Dept Nucl Med, DK-9000 Aalborg, Denmark..
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Radiology. Aalborg Univ Hosp, Dept Nucl Med, DK-9000 Aalborg, Denmark..
Aalborg Univ Hosp, Dept Nucl Med, DK-9000 Aalborg, Denmark..
Aalborg Univ Hosp, Dept Nucl Med, DK-9000 Aalborg, Denmark..
Show others and affiliations
2022 (English)In: Diagnostics, ISSN 2075-4418, Vol. 12, no 3, article id 681Article in journal (Refereed) Published
Abstract [en]

Background: The aim of this prospective study was to assess the diagnostic value of nuclear imaging with F-18-FDG PET/CT (FDG PET/CT), combined In-111-WBC/(99)mTc-Nanocoll, and Tc-99m-HDP SPECT/CT (dual-isotope WBC/bone marrow scan) for patients with chronic problems related to knee or hip prostheses (TKA or THA) scheduled by a structured multidisciplinary algorithm.

Materials and Methods: Fifty-five patients underwent imaging with Tc-99m-HDP SPECT/CT (bone scan), dual-isotope WBC/bone marrow scan, and FDG PET/CT. The final diagnosis of prosthetic joint infection (PJI) and/or loosening was based on the intraoperative findings and microbiological culture results and the clinical follow-up.

Results: The diagnostic performance of dual-isotope WBC/bone marrow SPECT/CT for PJI showed a sensitivity of 100% (CI 0.74-1.00), a specificity of 97% (CI 0.82-1.00), and an accuracy of 98% (CI 0.88-1.00); for PET/CT, the sensitivity, specificity, and accuracy were 100% (CI 0.74-1.00), 71% (CI 0.56-0.90), and 79% (CI 0.68-0.93), respectively.

Conclusions: In a standardized prospectively scheduled patient group, the results showed highly specific performance of combined dual-isotope WBC/bone marrow SPECT/CT in confirming chronic PJI. FDG PET/CT has an appropriate accuracy, but the utility of its use in the clinical diagnostic algorithm of suspected PJI needs further evidence.

Place, publisher, year, edition, pages
MDPI AG , 2022. Vol. 12, no 3, article id 681
Keywords [en]
hybrid imaging, nuclear imaging, FDG PET/CT, labeled leucocyte imaging, dual-isotope WBC/bone marrow scan, bone scan, prosthetic joint infection, periprosthetic infection
National Category
Radiology, Nuclear Medicine and Medical Imaging
Identifiers
URN: urn:nbn:se:uu:diva-472948DOI: 10.3390/diagnostics12030681ISI: 000775566600001PubMedID: 35328234OAI: oai:DiVA.org:uu-472948DiVA, id: diva2:1653467
Available from: 2022-04-22 Created: 2022-04-22 Last updated: 2022-04-22Bibliographically approved

Open Access in DiVA

fulltext(3904 kB)451 downloads
File information
File name FULLTEXT01.pdfFile size 3904 kBChecksum SHA-512
2d706646c35f4462ac894c26392029857df6850fb527e0d919c53f3c7953abd5503ffc90c29219b2bdebbdfe6ed170dee941095816f098b2400137b7d50e5a22
Type fulltextMimetype application/pdf

Other links

Publisher's full textPubMed

Search in DiVA

By author/editor
Iyer, VictorKappel, AndreasThomsen, Trine RolighedRasmussen, Sten
By organisation
Radiology
In the same journal
Diagnostics
Radiology, Nuclear Medicine and Medical Imaging

Search outside of DiVA

GoogleGoogle Scholar
Total: 454 downloads
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

doi
pubmed
urn-nbn

Altmetric score

doi
pubmed
urn-nbn
Total: 92 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf