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Whiplash injuries associated with experienced pain and disability can be visualized with [11C]-D-deprenyl positron emission tomography and computed tomography
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Anaesthesiology and Intensive Care.
Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Psychology.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Disciplinary Domain of Medicine and Pharmacy, research centers etc., Uppsala Clinical Research Center (UCR).ORCID iD: 0000-0002-3268-8810
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Radiology. PET Centre, Department of Medical Imaging, Uppsala University Hospital, Sweden.ORCID iD: 0000-0001-5738-9983
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2022 (English)In: Pain, ISSN 0304-3959, E-ISSN 1872-6623, Vol. 163, no 3, p. 489-495Article in journal (Refereed) Published
Abstract [en]

Knowledge of etiological mechanisms underlying whiplash-associated disorders is incomplete. Localisation and quantification of peripheral musculoskeletal injury and inflammation in whiplash-associated disorders would facilitate diagnosis, strengthen patients' subjective pain reports, and aid clinical decisions, all of which could lead to improved treatment. In this longitudinal observational study, we evaluated combined [11C]-D-deprenyl positron emission tomography and computed tomography after acute whiplash injury and at 6-month follow-up. Sixteen adult patients (mean age 33 years) with whiplash injury grade II were recruited at the emergency department. [11C]-D-deprenyl positron emission tomography and computed tomography, subjective pain levels, self-rated neck disability, and active cervical range of motion were recorded within 7 days after injury and again at 6-month follow-up. Imaging results showed possible tissue injuries after acute whiplash with an altered [11C]-D-deprenyl uptake in the cervical bone structures and facet joints, associated with subjective pain locale and levels, as well as self-rated disability. At follow-up, some patients had recovered and some showed persistent symptoms and reductions in [11C]-D-deprenyl uptake correlated to reductions in pain levels. These findings help identify affected peripheral structures in whiplash injury and strengthen the idea that positron emission tomography and computed tomography detectable organic lesions in peripheral tissue are relevant for the development of persistent pain and disability in whiplash injury.

Place, publisher, year, edition, pages
Lippincott Williams & Wilkins, 2022. Vol. 163, no 3, p. 489-495
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Physiotherapy
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URN: urn:nbn:se:uu:diva-456090DOI: 10.1097/j.pain.0000000000002381ISI: 000754035900020PubMedID: 34232928OAI: oai:DiVA.org:uu-456090DiVA, id: diva2:1603232
Available from: 2021-10-14 Created: 2021-10-14 Last updated: 2023-08-28Bibliographically approved

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Aarnio, MikkoFredrikson, MatsLampa, ErikSörensen, JensGordh, Torsten
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Anaesthesiology and Intensive CareDepartment of PsychologyUppsala Clinical Research Center (UCR)Radiology
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