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Changes in dopamine D2-receptor binding are associated to symptom reduction after psychotherapy in social anxiety disorder
Karolinska Univ, Hosp Solna, Karolinska Inst, Dept Clin Neurosci,Div Psychiat, S-17176 Stockholm, Sweden..ORCID iD: 0000-0001-8103-6977
Karolinska Univ, Hosp Solna, Karolinska Inst, Dept Clin Neurosci,Div Psychiat, S-17176 Stockholm, Sweden.;Karolinska Inst, Osher Ctr Integrat Med, Dept Clin Neurosci, Stockholm, Sweden.;Karolinska Inst, Div Psychol, Stockholm, Sweden..
Karolinska Univ, Hosp Solna, Karolinska Inst, Dept Clin Neurosci,Div Psychiat, S-17176 Stockholm, Sweden.;Natl Inst Radiol Sci, Mol Imaging Ctr, Chiba 260, Japan..
Karolinska Univ, Hosp Solna, Karolinska Inst, Dept Clin Neurosci,Div Psychiat, S-17176 Stockholm, Sweden..
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2012 (English)In: Translational Psychiatry, E-ISSN 2158-3188, Vol. 2, article id e120Article in journal (Refereed) Published
Abstract [en]

The dopamine system has been suggested to play a role in social anxiety disorder (SAD), partly based on molecular imaging studies showing reduced levels of striatal dopaminergic markers in patients compared with control subjects. However, the dopamine system has not been examined in frontal and limbic brain regions proposed to be central in the pathophysiology of SAD. In the present study, we hypothesized that extrastriatal dopamine D2-receptor (D2-R) levels measured using positron emission tomography (PET) would predict symptom reduction after cognitive behavior therapy (behavior). Nine SAD patients were examined using high-resolution PET and the high-affinity D2-R antagonist radioligand [C-11]FLB 457, before and after 15 weeks of CBT. Symptom levels were assessed using the anxiety subscale of Liebowitz Social Anxiety Scale (LSAS(anx)). At posttreatment, there was a statistically significant reduction of social anxiety symptoms (Po0.005). Using a repeated measures analysis of covariance, significant effects for time and time x LSAS(anx) change on D2-R-binding potential (BPND) were shown (P<0.05). In a subsequent region-by-region analysis, negative correlations between change in D2-R BPND and LSAS(anx) change were found for medial prefrontal cortex and hippocampus (P<0.05). This is the first study to report a direct relationship between symptom change after psychological treatment and a marker of brain P<0.05. Using an intra-individual comparison design, the study supports a role for the dopamine system in cortical and limbic brain regions in the pathophysiology of SAD. Translational Psychiatry (2012) 2, e120; doi:10.1038/tp.2012.40; published online 22 May 2012

Place, publisher, year, edition, pages
Springer Nature , 2012. Vol. 2, article id e120
Keywords [en]
CBT, dopamine, D2-receptor, PET, social anxiety disorder
National Category
Psychiatry
Identifiers
URN: urn:nbn:se:uu:diva-440748DOI: 10.1038/tp.2012.40ISI: 000312895700014PubMedID: 22832965OAI: oai:DiVA.org:uu-440748DiVA, id: diva2:1545912
Available from: 2021-04-20 Created: 2021-04-20 Last updated: 2024-01-17Bibliographically approved

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