Digitala Vetenskapliga Arkivet

Endre søk
RefereraExporteraLink to record
Permanent link

Direct link
Referera
Referensformat
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Annet format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annet språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf
18F-Radiolabeling and Preliminary Evaluation of a HSP90 ligand
Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Farmaceutiska fakulteten, Institutionen för läkemedelskemi, Preparativ läkemedelskemi.ORCID-id: 0000-0002-4334-7368
Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Farmaceutiska fakulteten, Institutionen för läkemedelskemi.
Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Endokrin tumörbiologi.
Vise andre og tillknytning
2021 (engelsk)Inngår i: European Journal of Pharmaceutical Sciences, ISSN 0928-0987, E-ISSN 1879-0720, Vol. 157, artikkel-id 105647Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

PURPOSE: With the ambition of improving the management of pancreatic neuroendocrine tumors (P-NETs), we developed and preliminary validated a novel fluorine-18 labelled HSP90 ligand.

METHODS: A precursor containing methoxymethyl ethers protecting groups and a tosyl as leaving group was synthesized. The target compound was labeled with nucleophilic 18F-fluoride and the protecting groups was subsequently removed with hydrochloric acid before purification. In vitro cell- and frozen section autoradiography and in vivo animal studies were performed.

RESULTS: The precursor was successfully synthesized and utilized in the 18F-radiolabeling giving 0.5-1.0 GBq of pure product with a synthesis time of 70 min. In vitro experiments indicated a high specific binding, but in vivo studies showed no tumor uptake due to fast hepatobiliary metabolism and excretion.

CONCLUSIONS: Despite the unfavorable in vivo properties of the tracer, the promising results from in vitro autoradiography experiments in frozen sections of P-NETs from surgical resection encourage us to continue the project aiming the improvement of in vivo properties of the tracer.

sted, utgiver, år, opplag, sider
Elsevier, 2021. Vol. 157, artikkel-id 105647
Emneord [en]
HSP90, PET, cancer, fluorine-18
HSV kategori
Forskningsprogram
Onkologi
Identifikatorer
URN: urn:nbn:se:uu:diva-428398DOI: 10.1016/j.ejps.2020.105647ISI: 000604553300012PubMedID: 33221456OAI: oai:DiVA.org:uu-428398DiVA, id: diva2:1509577
Forskningsfinansiär
Knut and Alice Wallenberg Foundation
Merknad

De två första författarna delar förstaförfattarskapet

Tilgjengelig fra: 2020-12-14 Laget: 2020-12-14 Sist oppdatert: 2024-01-15bibliografisk kontrollert

Open Access i DiVA

Fulltekst mangler i DiVA

Andre lenker

Forlagets fulltekstPubMed

Søk i DiVA

Av forfatter/redaktør
Nordeman, PatrikLi, Su-ChenLarhed, MatsAntoni, GunnarEstrada, SergioSelvaraju, Ram KumarÅberg, OlaStålberg, PeterSkogseid, BrittMonazzam, Azita
Av organisasjonen
I samme tidsskrift
European Journal of Pharmaceutical Sciences

Søk utenfor DiVA

GoogleGoogle Scholar

doi
pubmed
urn-nbn

Altmetric

doi
pubmed
urn-nbn
Totalt: 335 treff
RefereraExporteraLink to record
Permanent link

Direct link
Referera
Referensformat
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Annet format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annet språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf