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Probable role for major facilitator superfamily domain containing 6 (MFSD6) in the brain during variable energy consumption
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Pharmaceutical Biosciences.ORCID iD: 0000-0001-7235-3372
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Pharmaceutical Biosciences. Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Schiöth: Functional Pharmacology.ORCID iD: 0000-0001-6672-2442
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Pharmaceutical Biosciences.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Schiöth: Functional Pharmacology.
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2020 (English)In: International Journal of Neuroscience, ISSN 0020-7454, E-ISSN 1563-5279, Vol. 130, no 5, p. 476-489Article in journal (Refereed) Published
Abstract [en]

Purpose: The major facilitator superfamily (MFS) is known as the largest and most diverse superfamily containing human transporters, and these transporters are essential as they sustain the homeostasis within cellular compartments by moving substances over lipid membranes.

Methods: We have identified a novel MFS protein, named Major facilitator superfamily domain containing 6 (MFSD6), and confirmed that it is phylogenetically related to the human Solute Carrier (SLC) transporter family. A homology model of MFSD6 revealed 12 predicted transmembrane segments (TMS) with the classical MFS fold between TMS 6 and 7.

Results: Immunohistological analyses showed specific MFSD6 staining in neurons of wildtype mouse brain tissue, but no expression in astrocytes. Furthermore, we explored expression and probable function(s) of MFSD6 in relation to its phylogenetically related proteins, major facilitator superfamily domain containing 8 (MFSD8) and 10 (MFSD10), which is of interest as both these proteins are involved in diseases.

Conclusions: We showed that expression levels of Mfsd6 and Mfsd10 were decreased with elevated or depleted energy consumption, while that of Mfsd8 remained unaffected.

Place, publisher, year, edition, pages
Informa UK Limited , 2020. Vol. 130, no 5, p. 476-489
Keywords [en]
Transporter, energy metabolism, genetics, mRNA, molecular imaging, Major Facilitator Superfamily Domain containing 6 (MFSD6), human Solute Carrier (SLC) transporter family
National Category
Neurosciences
Identifiers
URN: urn:nbn:se:uu:diva-425753DOI: 10.1080/00207454.2019.1694020ISI: 000505860700001PubMedID: 31906755OAI: oai:DiVA.org:uu-425753DiVA, id: diva2:1505487
Funder
Swedish Research CouncilThe Swedish Brain FoundationSwedish Society for Medical Research (SSMF)Novo NordiskStiftelsen Olle Engkvist ByggmästareTore Nilsons Stiftelse för medicinsk forskningAvailable from: 2020-12-01 Created: 2020-12-01 Last updated: 2020-12-01Bibliographically approved

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