Digitala Vetenskapliga Arkivet

Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Evidence-based umbrella review of 162 peripheral biomarkers for major mental disorders
Univ Toronto, Canada; Ctr Addict and Mental Hlth CAMH, Canada.
Univ Padua, Italy; Kings Coll London, England.
Ctr Addict and Mental Hlth CAMH, Canada; Krembil Ctr NeuroInformat, Canada.
Womens Coll Hosp, Canada.
Show others and affiliations
2020 (English)In: Translational Psychiatry, E-ISSN 2158-3188, Vol. 10, no 1Article, review/survey (Refereed) Published
Abstract [en]

The literature on non-genetic peripheral biomarkers for major mental disorders is broad, with conflicting results. An umbrella review of meta-analyses of non-genetic peripheral biomarkers for Alzheimers disease, autism spectrum disorder, bipolar disorder (BD), major depressive disorder, and schizophrenia, including first-episode psychosis. We included meta-analyses that compared alterations in peripheral biomarkers between participants with mental disorders to controls (i.e., between-group meta-analyses) and that assessed biomarkers after treatment (i.e., within-group meta-analyses). Evidence for association was hierarchically graded using a priori defined criteria against several biases. The Assessment of Multiple Systematic Reviews (AMSTAR) instrument was used to investigate study quality. 1161 references were screened. 110 met inclusion criteria, relating to 359 meta-analytic estimates and 733,316 measurements, on 162 different biomarkers. Only two estimates met a priori defined criteria for convincing evidence (elevated awakening cortisol levels in euthymic BD participants relative to controls and decreased pyridoxal levels in participants with schizophrenia relative to controls). Of 42 estimates which met criteria for highly suggestive evidence only five biomarker aberrations occurred in more than one disorder. Only 15 meta-analyses had a power >0.8 to detect a small effect size, and most (81.9%) meta-analyses had high heterogeneity. Although some associations met criteria for either convincing or highly suggestive evidence, overall the vast literature of peripheral biomarkers for major mental disorders is affected by bias and is underpowered. No convincing evidence supported the existence of a trans-diagnostic biomarker. Adequately powered and methodologically sound future large collaborative studies are warranted.

Place, publisher, year, edition, pages
NATURE PUBLISHING GROUP , 2020. Vol. 10, no 1
National Category
Psychiatry
Identifiers
URN: urn:nbn:se:liu:diva-166483DOI: 10.1038/s41398-020-0835-5ISI: 000536853000004PubMedID: 32424116OAI: oai:DiVA.org:liu-166483DiVA, id: diva2:1444134
Note

Funding Agencies|National Institute for Health Research (NIHR)National Institute for Health Research (NIHR) [PDF-2018-11-ST2-020]; National Council for Scientific and Technological DevelopmentNational Council for Scientific and Technological Development (CNPq) [CNPQ-1B]; Program of Academic Productivity (PIPA) of the University of Sao Paulo Medical School; Pakistan Institute of Living and Learning (PILL); Physicians Services Incorporated (PSI) Foundation; Stanley Medical Research Institute (SMRI); Blackmores Institute Fellowship; NIH, Cooperative Research Centre; Cancer Council of VictoriaCanadian Institutes of Health Research (CIHR)Cancer Council Victoria; Stanley Medical Research Foundation; Medical Benefits Fund; National Health and Medical Research CouncilNational Health and Medical Research Council of Australia; Medical Research Futures Fund; Beyond Blue; Rotary Health; A2 milk company; Meat and Livestock Board; Woolworths; Avant; Harry Windsor Foundation; NHMRCNational Health and Medical Research Council of Australia [1059660, 1156072]; Alzheimers AssociationAlzheimers Association [PTC-18-543823]; National Institutes of HealthUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USA [R01AG046543]; Canadian Institutes for Health ResearchCanadian Institutes of Health Research (CIHR) [MOP 201803PJ8]; Alzheimers Drug Discovery Foundation [1012358]; Alzheimer Society of Canada [15-17]; Brain and Behaviour Foundation; Generalitat de Catalunya (PERIS); Spanish Ministry of Science, Innovation and Universities (CIBERSAM); EU Horizon 2020; Stanley Medical Research Institute; National Institute of Mental HealthUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USANIH National Institute of Mental Health (NIMH) [R37MH068376]; NARSAD Distinguished Investigator AwardNARSAD; Brain & Behavior Research FoundationNARSAD [26950]; Canadian Institute of Health ResearchCanadian Institutes of Health Research (CIHR); National Institute on AgingUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USANIH National Institute on Aging (NIA); Alzheimer Society of Canada; Alzheimers Association USAlzheimers Association; Alzheimers Drug Discovery Foundation

Available from: 2020-06-20 Created: 2020-06-20 Last updated: 2024-01-17

Open Access in DiVA

fulltext(722 kB)270 downloads
File information
File name FULLTEXT01.pdfFile size 722 kBChecksum SHA-512
a43ccc94f54311ffcb99459fb64ab9ec70e798acfbcf525c93b50d1df384f240b490b45b123d07eb04caadc1ba2f7915944141fb23d447139d42519bd9d1d2d3
Type fulltextMimetype application/pdf

Other links

Publisher's full textPubMed

Search in DiVA

By author/editor
Dragioti, Elena
By organisation
Division of Prevention, Rehabilitation and Community MedicineFaculty of Medicine and Health SciencesPain and Rehabilitation Center
In the same journal
Translational Psychiatry
Psychiatry

Search outside of DiVA

GoogleGoogle Scholar
Total: 270 downloads
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

doi
pubmed
urn-nbn

Altmetric score

doi
pubmed
urn-nbn
Total: 197 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf