Digitala Vetenskapliga Arkivet

Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
High Plasma Oxytocin Levels in Men With Hypersexual Disorder
Umeå University, Faculty of Medicine, Department of Clinical Sciences.ORCID iD: 0000-0001-6766-7983
Umeå University, Faculty of Medicine, Department of Clinical Sciences.
Show others and affiliations
2019 (English)In: Neuropsychopharmacology, ISSN 0893-133X, E-ISSN 1740-634X, Vol. 44, p. 114-114Article in journal, Meeting abstract (Other academic) Published
Abstract [en]

Background: Hypersexual disorder (HD) integrating pathophysiological aspects such as sexual desire deregulation, sexual addiction, impulsivity and compulsivity was suggested as a diagnosis for the DSM-5. "Compulsive Sexual Behavior Disorder" is now presented as an impulse-control disorder in ICD-11. Recent studies showed dysregulated HPA axis in men with HD. Oxytocin (OXT) affects the function of the HPA axis; no studies have assessed OXT levels in patients with HD. Whether a CBT treatment for HD symptoms has an effect on OXT levels has not been investigated.

Methods: We examined plasma OXT levels in 64 male patients with HD and 38 male age-matched healthy volunteers. Further, we examined correlations between plasma OXT levels and dimensional symptoms of HD using the rating scales measuring hypersexual behaviour: Hypersexual disorder screening inventory (HDSI) and the Sexual Compulsive scale (SCS). A part of the patients (N = 30) completed the manual-based group-administered CBT program for HD and had a secondary measurement of OXT at post-treatment. OXT was measured with Radioimmunoassay (RIA).

Results: Patients with HD had significantly higher OXT (Mean 31.0 ± SD 9.9 pM) levels compared to healthy volunteers (Mean 16.9 ± SD 3.9 pM) (p < 0.001). There were significant positive correlations between OXT levels and the rating scales measuring hypersexual behaviour (Spearman rhos between HDSI r = 0.649, p < 0.001 and SCS r = 0.629, p < 0.001) in the study participants combined. Patients who completed CBT treatment had significant reduction of OXT levels from pre-treatment (30.5 ± 10.1pM) to post-treatment (20.2 ± 8.0pM) (p < 0.001). Patients with HD had a significant positive correlation of their changes in HD:CAS with plasma oxytocin level before and after CBT(r = 0.388, p value= 0.0344).

Conclusions: The results suggest hyperactive oxytonergic system in male patients with hypersexual disorder which may be a compensatory mechanism to attenuate hyperactive stress system. A successful CBT group therapy may have effect on hyperactive oxytonergic system.

Place, publisher, year, edition, pages
Nature Publishing Group, 2019. Vol. 44, p. 114-114
Keywords [en]
Oxytocin and Addiction, Hypersexual Disorder, Cognitive Behavior Therapy
National Category
Pharmacology and Toxicology Neurosciences Psychiatry
Identifiers
URN: urn:nbn:se:umu:diva-168967ISI: 000509665600228OAI: oai:DiVA.org:umu-168967DiVA, id: diva2:1420877
Conference
58th Annual Meeting of the American-College-of-Neuropsychopharmacology (ACNP), DEC 08-11, 2019, Orlando, FL
Note

Supplement: 1

Meeting Abstract: M71

Available from: 2020-04-01 Created: 2020-04-01 Last updated: 2020-04-01Bibliographically approved

Open Access in DiVA

No full text in DiVA

Other links

URL

Search in DiVA

By author/editor
Jokinen, JussiChatzittofis, Andreas
By organisation
Department of Clinical Sciences
In the same journal
Neuropsychopharmacology
Pharmacology and ToxicologyNeurosciencesPsychiatry

Search outside of DiVA

GoogleGoogle Scholar

urn-nbn

Altmetric score

urn-nbn
Total: 7370 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf