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Neurocircuitry of Reward and Addiction: Potential Impact of Dopamine-Glutamate Co-release as Future Target in Substance Use Disorder
Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Organismal Biology, Comparative Physiology.ORCID iD: 0000-0002-8819-7957
Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Organismal Biology, Comparative Physiology.ORCID iD: 0000-0002-8713-070x
2019 (English)In: JOURNAL OF CLINICAL MEDICINE, ISSN 2077-0383, Vol. 8, no 11, article id 1887Article, review/survey (Refereed) Published
Abstract [en]

Dopamine-glutamate co-release is a unique property of midbrain neurons primarily located in the ventral tegmental area (VTA). Dopamine neurons of the VTA are important for behavioral regulation in response to rewarding substances, including natural rewards and addictive drugs. The impact of glutamate co-release on behaviors regulated by VTA dopamine neurons has been challenging to probe due to lack of selective methodology. However, several studies implementing conditional knockout and optogenetics technologies in transgenic mice have during the past decade pointed towards a role for glutamate co-release in multiple physiological and behavioral processes of importance to substance use and abuse. In this review, we discuss these studies to highlight findings that may be critical when considering mechanisms of importance for prevention and treatment of substance abuse.

Place, publisher, year, edition, pages
MDPI, 2019. Vol. 8, no 11, article id 1887
Keywords [en]
addiction, reward, transgenic mice, optogenetics, self-administration, cocaine, amphetamine
National Category
Neurology
Identifiers
URN: urn:nbn:se:uu:diva-402325DOI: 10.3390/jcm8111887ISI: 000502294400130PubMedID: 31698743OAI: oai:DiVA.org:uu-402325DiVA, id: diva2:1385557
Funder
Swedish Research CouncilThe Swedish Brain FoundationAvailable from: 2020-01-14 Created: 2020-01-14 Last updated: 2020-01-14Bibliographically approved

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