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Highly Reduced Survival in Essential Thrombocythemia and Polycythemia Vera Patients with Vascular Complications during Follow-up
Region Örebro län. Örebro universitet, Institutionen för medicinska vetenskaper. Department of Medicine.ORCID-id: 0000-0003-1928-7518
Department of Hematology, University Hospital Linköping, Linköping, Sweden.
Department of Medicine, Kalmar County Hospital, Sweden.
Division of Hematology, Specialist Medicine, NU Hospital Group, Uddevalla, Sweden.
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2020 (Engelska)Ingår i: European Journal of Haematology, ISSN 0902-4441, E-ISSN 1600-0609, Vol. 104, nr 3, s. 271-278Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

OBJECTIVE: To explore the relative importance of risk factors, treatments and blood counts for the occurrence of vascular complications and their impact on life expectancy in Essential Thrombocythemia (ET) and Polycythemia Vera (PV).

METHODS: Nested case-control study within the Swedish MPN registry. From a cohort of 922 ET patients and 763 PV patients, 71 ET and 81 PV cases with vascular complications were compared to matched controls.

RESULTS: Incidence of vascular complications were 2.0 and 3.4 events per 100 patient-years in ET and PV, respectively. At diagnosis, no significant risk factor differences were observed between cases and controls in neither of the diseases. At the time of vascular event, ET complication cases did not differ significantly from controls but in PV, cases had significantly higher WBCs and were to a lesser extent treated with antithrombotic and cytoreductive therapy. Life expectancy was significantly decreased in both ET and PV cases compared to controls.

CONCLUSIONS: The risk of vascular complications is high in both ET and PV and these complications have a considerable impact on life expectancy. The protective effect of antithrombotic and cytoreductive therapy for vascular complications in PV underscores the importance of avoiding undertreatment.

Ort, förlag, år, upplaga, sidor
Munksgaard Forlag, 2020. Vol. 104, nr 3, s. 271-278
Nyckelord [en]
Essential Thrombocythemia, Myeloproliferative neoplasms, Polycythemia Vera
Nationell ämneskategori
Kirurgi Hematologi
Identifikatorer
URN: urn:nbn:se:oru:diva-78899DOI: 10.1111/ejh.13373ISI: 000513873800014PubMedID: 31863513Scopus ID: 2-s2.0-85078796502OAI: oai:DiVA.org:oru-78899DiVA, id: diva2:1384652
Anmärkning

Funding Agency:

Regional FOU Västra Götaland County 

Tillgänglig från: 2020-01-10 Skapad: 2020-01-10 Senast uppdaterad: 2021-04-27Bibliografiskt granskad

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Ahlstrand, Erik
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Region Örebro länInstitutionen för medicinska vetenskaper
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European Journal of Haematology
KirurgiHematologi

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