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Systems biology perspective for studying the gut microbiota in human physiology and liver diseases
KTH, Centra, Science for Life Laboratory, SciLifeLab.ORCID-id: 0000-0002-2851-9651
Chalmers Univ Technol, Dept Biol & Biol Engn, Gothenburg, Sweden..
KTH, Centra, Science for Life Laboratory, SciLifeLab.ORCID-id: 0000-0002-4858-8056
Univ Gothenburg, Sahlgrenska Univ Hosp, Dept Mol & Clin Med, Gothenburg, Sweden..ORCID-id: 0000-0003-0786-8091
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2019 (Engelska)Ingår i: EBioMedicine, E-ISSN 2352-3964, Vol. 49, s. 364-373Artikel, forskningsöversikt (Refereegranskat) Published
Abstract [en]

The advancement in high-throughput sequencing technologies and systems biology approaches have revolutionized our understanding of biological systems and opened a new path to investigate unacknowledged biological phenomena. In parallel, the field of human microbiome research has greatly evolved and the relative contribution of the gut microbiome to health and disease have been systematically explored. This review provides an overview of the network-based and translational systems biology-based studies focusing on the function and composition of gut microbiota. We also discussed the association between the gut microbiome and the overall human physiology, as well as hepatic diseases and other metabolic disorders.

Ort, förlag, år, upplaga, sidor
ELSEVIER , 2019. Vol. 49, s. 364-373
Nyckelord [en]
Gut microbiome, Liver diseases, Host-microbiome interactions, Systems biology, Personalized medicine, Meta-omics, Biomarker, Metabolic models
Nationell ämneskategori
Bioinformatik och systembiologi
Identifikatorer
URN: urn:nbn:se:kth:diva-265189DOI: 10.1016/j.ebiom.2019.09.057ISI: 000497363700043PubMedID: 31636011Scopus ID: 2-s2.0-85073823469OAI: oai:DiVA.org:kth-265189DiVA, id: diva2:1380764
Forskningsfinansiär
Science for Life Laboratory - a national resource center for high-throughput molecular bioscience
Anmärkning

QC 20191219

Tillgänglig från: 2019-12-19 Skapad: 2019-12-19 Senast uppdaterad: 2020-01-10Bibliografiskt granskad

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Av författaren/redaktören
Altay, ÖzlemUhlén, MathiasBoren, JanMardinoglu, Adil
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Science for Life Laboratory, SciLifeLab
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EBioMedicine
Bioinformatik och systembiologi

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