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The human secretome
KTH, School of Engineering Sciences in Chemistry, Biotechnology and Health (CBH), Protein Science. KTH, Centres, Science for Life Laboratory, SciLifeLab. Tech Univ Denmark, Ctr Biosustainabil, Lyngby, Denmark.;Karolinska Inst, Dept Neurosci, Stockholm, Sweden..ORCID iD: 0000-0002-4858-8056
KTH, School of Engineering Sciences in Chemistry, Biotechnology and Health (CBH), Protein Science. KTH, Centres, Science for Life Laboratory, SciLifeLab.ORCID iD: 0000-0002-7000-4416
KTH, School of Engineering Sciences in Chemistry, Biotechnology and Health (CBH), Protein Science. KTH, Centres, Science for Life Laboratory, SciLifeLab.ORCID iD: 0000-0001-8947-2562
KTH, School of Engineering Sciences in Chemistry, Biotechnology and Health (CBH), Protein Science.
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2019 (English)In: Science Signaling, ISSN 1945-0877, E-ISSN 1937-9145, Vol. 12, no 609, article id eaaz0274Article in journal (Refereed) Published
Abstract [en]

The proteins secreted by human cells (collectively referred to as the secretome) are important not only for the basic understanding of human biology but also for the identification of potential targets for future diagnostics and therapies. Here, we present a comprehensive analysis of proteins predicted to be secreted in human cells, which provides information about their final localization in the human body, including the proteins actively secreted to peripheral blood. The analysis suggests that a large number of the proteins of the secretome are not secreted out of the cell, but instead are retained intracellularly, whereas another large group of proteins were identified that are predicted to be retained locally at the tissue of expression and not secreted into the blood. Proteins detected in the human blood by mass spectrometry-based proteomics and antibody-based immuno-assays are also presented with estimates of their concentrations in the blood. The results are presented in an updated version 19 of the Human Protein Atlas in which each gene encoding a secretome protein is annotated to provide an open-access knowledge resource of the human secretome, including body-wide expression data, spatial localization data down to the single-cell and subcellular levels, and data about the presence of proteins that are detectable in the blood.

Place, publisher, year, edition, pages
NLM (Medline) , 2019. Vol. 12, no 609, article id eaaz0274
National Category
Biochemistry and Molecular Biology Cell Biology
Identifiers
URN: urn:nbn:se:kth:diva-265462DOI: 10.1126/scisignal.aaz0274ISI: 000499099300003PubMedID: 31772123Scopus ID: 2-s2.0-85075677906OAI: oai:DiVA.org:kth-265462DiVA, id: diva2:1380234
Note

QC 20191218

Available from: 2019-12-18 Created: 2019-12-18 Last updated: 2020-01-10Bibliographically approved

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Uhlén, MathiasKarlsson, Max J.Hober, AndreasSvensson, Anne-SophieScheffel, JuliaKotol, DavidZhong, WenTebani, AbdellahStrandberg, LinneaEdfors, FredrikMardinoglu, AdilBerling, AnnaEkblad, SiriDannemeyer, MelanieKanje, SaraRockberg, JohanLundqvist, MagnusMalm, MagdalenaVolk, Anna-LuisaNilsson, PeterMånberg, AnnaDodig-Crnkovic, Teavon Feilitzen, KalleHäussler, Ragna S.Hong, Mun-GwanAyoglu, BurcuMahdessian, DianaSullivan, DevinThul, PeterDanielsson, FridaStadler, CharlotteLundberg, EmmaTegel, HannaHober, SophiaForsström, BjörnSchwenk, Jochen M.Fagerberg, LinnSivertsson, Åsa
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