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At the Heart of Cognitive Functioning in Aging
Umeå University, Faculty of Medicine, Department of Radiation Sciences. Umeå University, Faculty of Medicine, Umeå Centre for Functional Brain Imaging (UFBI).ORCID iD: 0000-0001-6784-1945
Umeå University, Faculty of Medicine, Department of Radiation Sciences. Umeå University, Faculty of Medicine, Department of Integrative Medical Biology (IMB). Umeå University, Faculty of Medicine, Umeå Centre for Functional Brain Imaging (UFBI).
2019 (English)In: Trends in cognitive sciences, ISSN 1364-6613, E-ISSN 1879-307X, Vol. 23, no 9, p. 717-720Article in journal, Editorial material (Other academic) Published
Abstract [en]

Several neural and non-neural factors contribute to individual differences in cognitive performance. Here we outline a sequence of vascular events where excessive transfer of arterial-pressure pulsatility damages hippocampal capillaries. We argue that the vascular alterations decrease the ability to sustain neural activity and thereby contribute to episodic-memory impairment in aging.

Place, publisher, year, edition, pages
Elsevier, 2019. Vol. 23, no 9, p. 717-720
Keywords [en]
episodic memory, brain maintenance, vascular, blood–brain barrier, arteries, neurovascular coupling, hippocampus
National Category
Neurosciences Psychology Cardiac and Cardiovascular Systems
Identifiers
URN: urn:nbn:se:umu:diva-162831DOI: 10.1016/j.tics.2019.06.004ISI: 000480652500003PubMedID: 31303538OAI: oai:DiVA.org:umu-162831DiVA, id: diva2:1351484
Available from: 2019-09-16 Created: 2019-09-16 Last updated: 2019-09-16Bibliographically approved

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Wåhlin, AndersNyberg, Lars
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