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Reference Intervals for Fecal Calprotectin in Pregnant Women Using a Particle Enhanced Turbidimetric Assay
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Molecular epidemiology. Uppsala University, Science for Life Laboratory, SciLifeLab.ORCID iD: 0000-0003-2071-5866
Karolinska Institutet.
Karolinska Institutet.
Karolinska Institutet.
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2019 (English)In: Clinical Laboratory, ISSN 1433-6510, Vol. 65, no 7, p. 1293-1297Article in journal (Refereed) Published
Abstract [en]

BACKGROUND: Fecal calprotectin is widely used as a marker for inflammatory bowel diseases (IBD). IBD often affects women during their reproductive years, but there are no established reference intervals during pregnancy. The aim of the present study was to define reference values during pregnancy and in the postpartum period to allow comparisons between patient results and reference values.

METHODS: Fecal samples were collected from 84 healthy females during pregnancy week 26 to 28 and a second sample was collected six months after delivery. The samples were weighed, extracted, and centrifugated to remove debris. The extracted samples were then analyzed on a chemistry analyzer using a particle enhanced turbidimetric immunoassay reagent.

RESULTS: The calculated reference interval during pregnancy was < 127 μg/g (90% confidence interval, 90 - 164 μg/g) and the corresponding reference interval during the postpartum period was < 143 μg/g (60 - 226 μg/g). There were no significant statistical differences between F-calprotectin values analyzed at the two sampling times.

CONCLUSIONS: The reference values are slightly higher than the cutoff values of 50 - 100 μg/g often used as General cutoff for fecal calprotectin.

Place, publisher, year, edition, pages
2019. Vol. 65, no 7, p. 1293-1297
Keywords [en]
biological markers, calprotectin, feces, inflammatory bowel diseases, reference interval, pregnancy
National Category
Clinical Laboratory Medicine
Identifiers
URN: urn:nbn:se:uu:diva-389529DOI: 10.7754/Clin.Lab.2019.190104ISI: 000475700400020PubMedID: 31307176OAI: oai:DiVA.org:uu-389529DiVA, id: diva2:1337770
Funder
Swedish Heart Lung Foundation, 20150429Knut and Alice Wallenberg FoundationSwedish Research Council, 2015-03477VinnovaErik, Karin och Gösta Selanders FoundationGöran Gustafsson Foundation for promotion of scientific research at Uppala University and Royal Institute of TechnologySwedish Research Council, 340-2013-5867Swedish Asthma and Allergy AssociationStockholm County CouncilForte, Swedish Research Council for Health, Working Life and WelfareAvailable from: 2019-07-17 Created: 2019-07-17 Last updated: 2019-08-23Bibliographically approved

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