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A sensitive method detecting trace levels of levonorgestrel using LC-HRMS.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Clinical Chemistry.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Women's and Children's Health, Research group (Dept. of women´s and children´s health), Reproductive biology.
Department of Marine Sciences, University of Gothenburg, Carl Skottbergs gata 22B, SE-41319 Gothenburg, Sweden..
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Clinical pharmacogenomics and osteoporosis.
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2019 (English)In: Contraception, ISSN 0010-7824, E-ISSN 1879-0518, Vol. 100, no 3, p. 247-249Article in journal (Refereed) Published
Abstract [en]

OBJECTIVE: To develop a high resolution mass spectrometry (HRMS) method to quantify levonorgestrel (LNG) in serum.

STUDY DESIGN: Levonorgestrel was extracted using solid phase extraction and measured using liquid chromatography (LC) HRMS.

RESULTS: Low limit of quantification (LLOQ) was 25pg/mL and low limit of detection (LLOD) was 12.5pg/mL. Precision and accuracy bias were<10%. LNG in serum samples from Mirena® users ranged between 37 to 219pg/mL (n=12). In eight out of 22 patients with suspected intrauterine device (IUD) expulsion LNG was detected (26 to 1272pg/mL).

CONCLUSION: A sensitive, fast and simple LC-HRMS method was developed to detect trace levels of LNG.

Place, publisher, year, edition, pages
2019. Vol. 100, no 3, p. 247-249
Keywords [en]
High resolution mass spectrometry, Intrauterine device, Liquid chromatography, Lower limit of quantification, Solid phase extraction
National Category
Obstetrics, Gynecology and Reproductive Medicine
Identifiers
URN: urn:nbn:se:uu:diva-388593DOI: 10.1016/j.contraception.2019.06.001ISI: 000483452100015PubMedID: 31216423OAI: oai:DiVA.org:uu-388593DiVA, id: diva2:1334174
Available from: 2019-07-02 Created: 2019-07-02 Last updated: 2019-10-17Bibliographically approved

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