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Galantamine plasma concentration and cognitive response in Alzheimer's disease
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Molecular epidemiology. Kaohsiung Med Univ, Kaohsiung Med Univ Hosp, Dept Family Med, Kaohsiung, Taiwan.
Kaohsiung Med Univ, Kaohsiung Med Univ Hosp, Dept Neurol, Kaohsiung, Taiwan;Kaohsiung Med Univ, Kaohsiung Municipal Ta Tung Hosp, Dept Neurol, Kaohsiung, Taiwan.
Kaohsiung Med Univ, Dept Med Lab Sci & Biotechnol, Kaohsiung, Taiwan.
Kaohsiung Med Univ, Kaohsiung Med Univ Hosp, Dept Neurol, Kaohsiung, Taiwan;Kaohsiung Med Univ, Kaohsiung Municipal Ta Tung Hosp, Dept Neurol, Kaohsiung, Taiwan;Kaohsiung Med Univ, Fac Med, Dept Neurol, Kaohsiung, Taiwan;Kaohsiung Med Univ, Fac Med, Masters Program Neurol, Kaohsiung, Taiwan;Kaohsiung Med Univ, Neurosci Res Ctr, Kaohsiung, Taiwan.
2019 (English)In: PeerJ, ISSN 2167-8359, E-ISSN 2167-8359, Vol. 7, article id e6887Article in journal (Refereed) Published
Abstract [en]

Background

Galantamine has been approved for the treatment of Alzheimer's disease (AD). However, there are few studies which have reported the association between cognitive responses and galantamine plasma concentration. The aim of this study was to determine the correlation between galantamine plasma concentration and the subsequent cognitive response following treatment in AD patients.

Methods

ADsufferers who continuously took 8 mg/d galantamine for at least 6 months without previous exposure to other kinds of AChEI such as donepezil, rivastigmine, or memantine were included in this cohort study. The assessments included the Mini Mental Status Examination (MMSE), Clinical Dementia Rating Scale (CDR) and the Cognitive Assessment Screening Instrument (CASI). Each subdomain of the CASI assessment was conducted at baseline and after 6 months of galantamine. The plasma concentrations of galantamine were measured by capillary electrophoresis after 6 months of the treatment. Logistic regression was performed to adjust for age, gender, apolipoprotein E epsilon 4 genotype status, and baseline score to investigate the association between galantamine plasma concentrations and the cognitive response.

Results

The total sample consisted of 33 clinically diagnosed AD patients taking galantamine 8 mg/d for 6 months. There was no linear correlation between galantamine concentration and cognitive response in patients. However, 22 patients were responsive to the treatment in the long-term memory domain. In CASI subset domain, concentration improved during the 6 months follow up.

Conclusions

In the limited samples study, galantamine mostly benefitted the cognitive domain of long-term memory. The benefits were not related to the galantamine plasma concentration. Objective intra-individual evaluation of therapeutic response should be encouraged.

Place, publisher, year, edition, pages
2019. Vol. 7, article id e6887
Keywords [en]
Alzheimer's disease, Galantamine, Cognitive response, Cholinesterase inhibitors, MMSE
National Category
Psychiatry Neurology
Identifiers
URN: urn:nbn:se:uu:diva-383504DOI: 10.7717/peerj.6887ISI: 000466458700007OAI: oai:DiVA.org:uu-383504DiVA, id: diva2:1316417
Available from: 2019-05-17 Created: 2019-05-17 Last updated: 2019-05-17Bibliographically approved

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