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Accuracy of determination of the glomerular filtration marker iohexol by European laboratories as monitored by external quality assessment
Equalis, Uppsala, Sweden.
Equalis, Uppsala, Sweden.
Equalis, Uppsala, Sweden.
Landstinget Varmland, Dept Clin Chem, Karlstad, Sweden.
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2019 (English)In: Clinical Chemistry and Laboratory Medicine, ISSN 1434-6621, E-ISSN 1437-4331, Vol. 57, no 7, p. 1006-1011Article in journal (Refereed) Published
Abstract [en]

Background Glomerular filtration is the most important kidney function. The most accurate glomerular filtration rate (GFR) estimates are based on the clearance of exogenous filtration markers. Of these, iohexol is the only exogenous marker that is included in an external quality assessment (EQA) scheme. The aim of the present study was to evaluate the performance of the European laboratories participating in Equalis' EQA scheme for iohexol. Methods Weighed amounts of iohexol (Omnipaque) were added to plasma samples and distributed to laboratories participating in the EQA scheme for iohexol. All laboratories performed the assays in a blinded fashion. Results The number of participating laboratories varied between 27 and 34 during the study period. Iohexol was determined by HPLC in 77% of the laboratories and by UPLC/MS/MS methods in 15% of the laboratories. The mean interlaboratory coefficient of variation was 4.7% for the HPLC methods and 6.4% for the UPLC/MS/MS methods. The mean bias between calculated and measured iohexol values was -1.3 mg/L (95% confidence interval ±0.3) during the first part of the study period and 0.1 mg/L (±0.3) during the later part. Conclusions The low interlaboratory variation demonstrates that iohexol can be measured reliably by many laboratories and supports the use of iohexol as a GFR marker when there is a need for high quality GFR measurements.

Place, publisher, year, edition, pages
Walter de Gruyter, 2019. Vol. 57, no 7, p. 1006-1011
Keywords [en]
GFR, external quality assessment scheme, glomerular filtration rate, iohexol
National Category
Clinical Laboratory Medicine
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URN: urn:nbn:se:uu:diva-383248DOI: 10.1515/cclm-2018-1175ISI: 000470676100019PubMedID: 31075079OAI: oai:DiVA.org:uu-383248DiVA, id: diva2:1315119
Available from: 2019-05-11 Created: 2019-05-11 Last updated: 2019-06-26Bibliographically approved

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