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A research pathway for the study of the delivery and disposition of nebulised antibiotics: an incremental approach from in vitro to large animal models
Faculty of Medicine, UQ Centre for Clinical Research, The University of Queensland, Brisbane, Australia. jadhanani@hotmail.com; Department of Intensive Care Medicine, Royal Brisbane and Womens Hospital, Brisbane, Australia. jadhanani@hotmail.com; Critical Care Research Group, The University of Queensland, Brisbane, Australia.
Faculty of Medicine, UQ Centre for Clinical Research, The University of Queensland, Brisbane, Australia; Department of Intensive Care Medicine, Royal Brisbane and Womens Hospital, Brisbane, Australia.
Faculty of Medicine, UQ Centre for Clinical Research, The University of Queensland, Brisbane, Australia.
Advanced Drug Delivery Group, Faculty of Pharmacy, The University of Sydney, Sydney, New South Wales, Australia.
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2018 (English)In: Intensive Care Medicine Experimental, ISSN 1646-2335, E-ISSN 2197-425X, Vol. 6, no 1, article id 17Article in journal (Refereed) Published
Abstract [en]

Nebulised antibiotics are frequently used for the prevention or treatment of ventilator-associated pneumonia. Many factors may influence pulmonary drug concentrations with inaccurate dosing schedules potentially leading to therapeutic failure and/or the emergence of antibiotic resistance. We describe a research pathway for studying the pharmacokinetics of a nebulised antibiotic during mechanical ventilation using in vitro methods and ovine models, using tobramycin as the study antibiotic.

Place, publisher, year, edition, pages
2018. Vol. 6, no 1, article id 17
Keywords [en]
Inhaled mass; Microdialysis; Nebulised antibiotics; Particle size distribution; Regional drug distribution; Ventilator-associated pneumonia
National Category
Anesthesiology and Intensive Care
Identifiers
URN: urn:nbn:se:liu:diva-155996DOI: 10.1186/s40635-018-0180-7PubMedID: 29998357OAI: oai:DiVA.org:liu-155996DiVA, id: diva2:1301092
Available from: 2019-04-01 Created: 2019-04-01 Last updated: 2019-09-19

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Chew, Michelle S
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Division of Drug ResearchFaculty of Medicine and Health SciencesDepartment of Anaesthesiology and Intensive Care in Linköping
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