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2019 (English)In: Aging Clinical and Experimental Research, ISSN 1594-0667, E-ISSN 1720-8319, Vol. 31, no 8, p. 1078-1095Article in journal (Refereed) Published
Abstract [en]
Background
Falls and related injuries are common among older people, and several drug classes are considered to increase fall risk.
Aims
This study aimed to investigate the association between the use of certain drug classes and falls in older nursing home residents in Sweden, and relate these to different age groups.
Methods
Information on falls that occurred in the previous year and regular use of possible fall risk drugs including non-benzodiazepine hypnotics (zopiclone and zolpidem) was collected from 331 nursing home residents during 2008–2011. Over the following 6 months, the occurrence of serious falls, requiring a physician visit or hospital care, was registered. Association between serious falls and drug use was compared between an older (≥ 85 years) and a younger group.
Results
An increased fall risk (Downton Fall Risk Index ≥ 3) was found in 93% of the study subjects (aged 65–101 years). Baseline data indicated an association between falls that occurred in the previous year and regular use of non-benzodiazepine hypnotics (p = 0.005), but not with the other studied drug classes. During the following 6 months, an association between use of non-benzodiazepine hypnotics and serious falls in the older group (p = 0.017, odds ratio 4.311) was found. No association was found between the other studied drug classes and serious falls.
Discussion
These results indicate an association between falls and the use of non-benzodiazepine hypnotics, compounds that previously have been considered generally well-tolerated in older people.
Conclusions
Caution is advocated when using non-benzodiazepine hypnotics regularly in older people living in nursing homes.
Place, publisher, year, edition, pages
Springer, 2019
Keywords
Accidental falls, Frail elderly, Nursing homes, Hypnotics and sedatives, Adverse effects, Longitudinal study
National Category
Rheumatology and Autoimmunity Geriatrics Pharmacology and Toxicology
Identifiers
urn:nbn:se:liu:diva-156240 (URN)10.1007/s40520-018-1056-0 (DOI)000477664800007 ()30341643 (PubMedID)2-s2.0-85055751099 (Scopus ID)
Note
Funding agencies: Medical Research Council of Southeast Sweden (FORSS); Futurum-Academy of Health and Care, Region Jonkoping County
2019-04-092019-04-092021-10-04Bibliographically approved