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Pathophysiology behind prolonged whiplash associated disorders: study protocol for an experimental study
Linköping University, Department of Medical and Health Sciences, Division of Physiotherapy. Linköping University, Faculty of Medicine and Health Sciences.ORCID iD: 0000-0002-6075-4432
Linköping University, Department of Biomedical Engineering, Division of Biomedical Engineering. Linköping University, Faculty of Science & Engineering. Linköping University, Center for Medical Image Science and Visualization (CMIV).
Linköping University, Department of Medical and Health Sciences, Division of Community Medicine. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Anaesthetics, Operations and Specialty Surgery Center, Pain and Rehabilitation Center.
Linköping University, Department of Medical and Health Sciences, Division of Cardiovascular Medicine. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Heart and Medicine Center, Department of Clinical Physiology in Linköping. Linköping University, Center for Medical Image Science and Visualization (CMIV).ORCID iD: 0000-0003-1395-8296
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2019 (English)In: BMC Musculoskeletal Disorders, ISSN 1471-2474, E-ISSN 1471-2474, Vol. 20, article id 51Article in journal (Refereed) Published
Abstract [en]

BackgroundThere is insufficient knowledge of pathophysiological parameters to understand the mechanism behind prolonged whiplash associated disorders (WAD), and it is not known whether or not changes can be restored by rehabilitation. The aims of the projects are to investigate imaging and molecular biomarkers, cervical kinaesthesia, postural sway and the association with pain, disability and other outcomes in individuals with longstanding WAD, before and after a neck-specific exercise intervention. Another aim is to compare individuals with WAD with healthy controls.MethodsParticipants are a sub-group (n=30) of individuals recruited from an ongoing randomized controlled study (RCT). Measurements in this experimental prospective study will be carried out at baseline (before intervention) and at a three month follow-up (end of physiotherapy intervention), and will include muscle structure and inflammation using magnetic resonance imaging (MRI), brain structure and function related to pain using functional MRI (fMRI), muscle function using ultrasonography, biomarkers using samples of blood and saliva, cervical kinaesthesia using the butterfly test and static balance test using an iPhone app. Association with other measures (self-reported and clinical measures) obtained in the RCT (e.g. background data, pain, disability, satisfaction with care, work ability, quality of life) may be investigated. Healthy volunteers matched for age and gender will be recruited as controls (n=30).DiscussionThe study results may contribute to the development of improved diagnostics and improved rehabilitation methods for WAD.Trial registrationClinicaltrial.gov Protocol ID: NCT03664934, initial release 09/11/2018.

Place, publisher, year, edition, pages
BMC , 2019. Vol. 20, article id 51
Keywords [en]
Whiplash injury; Neck; Spine; Chronic; Physiotherapy; Rehabilitation; Exercise therapy; Randomized; Follow-up study; Outcome; Physiopathology; Diagnostic imaging; MRI; Scan; Ultrasonography; Biomarkers
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Physiotherapy
Identifiers
URN: urn:nbn:se:liu:diva-154558DOI: 10.1186/s12891-019-2433-3ISI: 000457465500001PubMedID: 30711003OAI: oai:DiVA.org:liu-154558DiVA, id: diva2:1290512
Note

Funding Agencies|Swedish Research Council; Ostergotland County Council, Sweden; Sormland County Council, Sweden

Available from: 2019-02-20 Created: 2019-02-20 Last updated: 2019-03-26

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Peolsson, AnneliKarlsson, AnetteGhafouri, BijarEbbers, TinoEngström, MariaJönsson, MargarethaWåhlén, KarinRomu, ThobiasBorga, MagnusZsigmond, PeterPeterson, Gunnel
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Division of PhysiotherapyFaculty of Medicine and Health SciencesDivision of Biomedical EngineeringFaculty of Science & EngineeringCenter for Medical Image Science and Visualization (CMIV)Division of Community MedicinePain and Rehabilitation CenterDivision of Cardiovascular MedicineDepartment of Clinical Physiology in LinköpingDivision of Radiological SciencesDepartment of Biomedical EngineeringDivision of Neuro and Inflammation ScienceDepartment of Neurosurgery
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