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Low sub-minimal inhibitory concentrations of antibiotics generate new types of resistance
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Biochemistry and Microbiology.
2019 (English)In: Sustainable Chemistry and Pharmacy, ISSN 2352-5541, Vol. 11, p. 46-48Article in journal (Refereed) Published
Abstract [en]

Antibiotic resistance is a major threat to modern medicine. Routes of transmission of resistant bacteria are complex and include spread between humans, between humans and animals, between animals and to humans and animals via the environment. Recent findings have shown that resistant bacteria can be selectively enriched even at antibiotic concentrations several hundred-fold lower than previously expected, such as those found in sewage water. In addition, these low concentrations can select for high level resistant bacteria with very low fitness cost in contrast to resistant bacteria selected at high concentrations such as during antibiotic treatment of patients. This calls for action to determine what concentrations and combinations of antibiotics that can be considered safe in waste water and ensure proper measures to reduce the antropogenic contamination with antibiotics.

Place, publisher, year, edition, pages
2019. Vol. 11, p. 46-48
Keywords [en]
Antibiotic resistance, Selection, Sewage, Contamination
National Category
Medicinal Chemistry
Identifiers
URN: urn:nbn:se:uu:diva-375793DOI: 10.1016/j.scp.2018.12.006ISI: 000455920800007OAI: oai:DiVA.org:uu-375793DiVA, id: diva2:1289364
Funder
Swedish Research Council Formas, 2016-00642Available from: 2019-02-18 Created: 2019-02-18 Last updated: 2019-02-18Bibliographically approved

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