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Epigenetic alterations in primary Sjogren's syndrome: an overview
Uppsala University, Science for Life Laboratory, SciLifeLab. Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Rheumatology.ORCID iD: 0000-0002-7230-8990
Uppsala University, Science for Life Laboratory, SciLifeLab. Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Rheumatology.ORCID iD: 0000-0003-1382-2321
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Rheumatology. Uppsala University, Science for Life Laboratory, SciLifeLab.ORCID iD: 0000-0002-3829-7431
2018 (English)In: Clinical Immunology, ISSN 1521-6616, E-ISSN 1521-7035, Vol. 196, p. 12-20Article in journal (Refereed) Published
Abstract [en]

Primary Sjogren's syndrome (pSS) is a chronic autoimmune rheumatic disease characterized by inflammation of exocrine glands, mainly salivary and lacrimal glands. In addition, pSS may affect multiple other organs resulting in systemic manifestations. Although the precise etiology of pSS remains elusive, pSS is considered to be a multi factorial disease, where underlying genetic predisposition, environmental factors and epigenetic mechanisms contribute to disease development. Epigenetic mechanisms, such as DNA methylation, histone modifications and non-coding RNAs, may constitute a dynamic link between genome, environment and phenotypic manifestation by their modulating effects on gene expression. A growing body of studies reporting altered epigenetic landscapes in pSS suggests that epigenetic mechanisms play a role in the pathogenesis of pSS, and the reversible nature of epigenetic modifications suggests therapeutic strategies targeting epigenetic dysregulation in pSS. This article reviews our current understanding of epigenetic mechanisms in pSS and discusses implications for novel diagnostic and therapeutic approaches.

Place, publisher, year, edition, pages
2018. Vol. 196, p. 12-20
Keywords [en]
Primary Sjogren's syndrome (pSS), Epigenetics, DNA methylation, Histone modification, Non-coding RNA (ncRNA), Interferon (IFN)
National Category
Rheumatology and Autoimmunity Immunology in the medical area
Identifiers
URN: urn:nbn:se:uu:diva-373212DOI: 10.1016/j.clim.2018.04.004ISI: 000454373800003PubMedID: 29649576OAI: oai:DiVA.org:uu-373212DiVA, id: diva2:1278038
Funder
Swedish Research Council, 2016-01982AstraZenecaAvailable from: 2019-01-11 Created: 2019-01-11 Last updated: 2019-01-11Bibliographically approved

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