Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Longitudinal changes in leukocyte telomere length and mortality in elderly Swedish men
Karolinska Inst, Div Hematol, Dept Med, SE-17176 Stockholm, Sweden;Karolinska Inst, Ctr Mol Med, SE-17176 Stockholm, Sweden;Karolinska Univ Hosp Solna, SE-17176 Stockholm, Sweden.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences, Clinical Nutrition and Metabolism.
Karolinska Univ Hosp, Karolinska Inst, Dept Med, SE-17176 Solna, Sweden.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences, Clinical Nutrition and Metabolism.ORCID iD: 0000-0003-3705-0725
Show others and affiliations
2018 (English)In: Aging, ISSN 1945-4589, E-ISSN 1945-4589, Vol. 10, no 10, p. 3005-3016Article in journal (Refereed) Published
Abstract [en]

Telomere length (TL) is considered an indicator of aging and age-related diseases, but longitudinal studies on TL changes and mortality are few. We therefore analyzed TL and longitudinal changes in TL in relation to all-cause, cardiovascular, and cancer mortality in 247 elderly Swedish men. TL was determined by the qPCR method at ages 71 and 81 and subsequent mortality cases were identified from the Swedish cause-of-death registry. Cox proportional hazard ratios were calculated during a mean follow-up of 7.4 years, during which 178 deaths occurred. Short telomeres at baseline was strongly associated with mortality risks, with a 40 to 70% increased risk of all-cause mortality, and a 2-fold increased risk of cancer mortality. Longitudinal changes in TL revealed shortening in 83% of individuals, whilst 10% extended their telomeres. TL attrition did not predict all-cause or cancer mortality, but we found a 60% decreased risk for cardiovascular mortality in those who shortened their telomeres. Our data show an increased risk of mortality in individuals with short baseline telomeres, but no relations to all-cause, and cancer mortality for changes in TL. Intriguingly, our data indicate lower risk of cardiovascular mortality with shortening of telomeres. The latter should be interpreted cautiously.

Place, publisher, year, edition, pages
IMPACT JOURNALS LLC , 2018. Vol. 10, no 10, p. 3005-3016
Keywords [en]
telomere length, longitudinal changes, mortality, cause-specific mortality, cohort study
National Category
Cardiac and Cardiovascular Systems
Identifiers
URN: urn:nbn:se:uu:diva-372677DOI: 10.18632/aging.101611ISI: 000451851600041PubMedID: 30375983OAI: oai:DiVA.org:uu-372677DiVA, id: diva2:1277042
Funder
Swedish Research CouncilSwedish Cancer SocietyThe Cancer Society in StockholmAvailable from: 2019-01-09 Created: 2019-01-09 Last updated: 2019-01-09Bibliographically approved

Open Access in DiVA

fulltext(581 kB)37 downloads
File information
File name FULLTEXT01.pdfFile size 581 kBChecksum SHA-512
6cbc9afa9401fad1585d02fd80e289c683cc7c73b94788943cec9aa065b3efe3fe05c10144a8739efb9e184d6c6308ac404297e514a6af7799a7313631fa33f0
Type fulltextMimetype application/pdf

Other links

Publisher's full textPubMed

Search in DiVA

By author/editor
Cederholm, TommySjögren, Per
By organisation
Clinical Nutrition and Metabolism
In the same journal
Aging
Cardiac and Cardiovascular Systems

Search outside of DiVA

GoogleGoogle Scholar
Total: 37 downloads
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

doi
pubmed
urn-nbn

Altmetric score

doi
pubmed
urn-nbn
Total: 45 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf