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Rapid Increase in Carriage Rates of Enterobacteriaceae Producing Extended-Spectrum β-Lactamases in Healthy Preschool Children, Sweden
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Women's and Children's Health, Research group (Dept. of women´s and children´s health), Paediatric Inflammation Research.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Infection medicine.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Pharmaceutical Biosciences.ORCID iD: 0000-0001-6770-0878
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2018 (English)In: Emerging Infectious Diseases, ISSN 1080-6040, E-ISSN 1080-6059, Vol. 24, no 10, p. 1874-1881Article in journal (Refereed) Published
Abstract [en]

By collecting and analyzing diapers, we identified a >6-fold increase in carriage of extended-spectrum β-lactamase (ESBL)-producing Enterobacteriaceae for healthy preschool children in Sweden (p<0.0001). For 6 of the 50 participating preschools, the carriage rate was >40%. We analyzed samples from 334 children and found 56 containing >1 ESBL producer. The prevalence in the study population increased from 2.6% in 2010 to 16.8% in 2016 (p<0.0001), and for 6 of the 50 participating preschools, the carriage rate was >40%. Furthermore, 58% of the ESBL producers were multidrug resistant, and transmission of ESBL-producing and non-ESBL-producing strains was observed at several of the preschools. Toddlers appear to be major carriers of ESBL producers in Sweden.

Place, publisher, year, edition, pages
2018. Vol. 24, no 10, p. 1874-1881
Keywords [en]
AmpC, ESBLs, Enterobacteriaceae, Sweden, antimicrobial resistance, bacteria, carriage rates, cephalosporin resistance, enteric infections, extended-spectrum β-lactamases, healthy preschool children, preschool children, respiratory infections, whole-genome sequencing
National Category
Public Health, Global Health, Social Medicine and Epidemiology
Identifiers
URN: urn:nbn:se:uu:diva-368814DOI: 10.3201/eid2410.171842ISI: 000444801900011PubMedID: 30226162OAI: oai:DiVA.org:uu-368814DiVA, id: diva2:1269049
Funder
Swedish Research CouncilScience for Life Laboratory - a national resource center for high-throughput molecular bioscienceSwedish Research Council FormasAvailable from: 2018-12-07 Created: 2018-12-07 Last updated: 2019-02-01Bibliographically approved

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Kaarme, JohanRiedel, Hilde M.Schaal, WesleyNevéus, TryggveMelhus, Åsa
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