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Maltreatment, the Oxytocin Receptor Gene, and Conduct Problems Among Male and Female Teenagers
Department of Clinical Neuroscience, Karolinska Institute, Stockholm, Sweden; 1st Department of Psychiatry, National and Kapodistrian University of Athens, Athens, Greece.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience. Uppsala University, Science for Life Laboratory, SciLifeLab.ORCID iD: 0000-0002-2174-2068
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm, Centre for Clinical Research, County of Västmanland.ORCID iD: 0000-0002-3589-6113
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm, Centre for Clinical Research, County of Västmanland.ORCID iD: 0000-0002-8853-2508
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2018 (English)In: Frontiers in Human Neuroscience, ISSN 1662-5161, E-ISSN 1662-5161, Vol. 12, article id 112Article in journal (Refereed) Published
Abstract [en]

The oxytocin receptor gene (OXTR) influences human behavior. The G allele of OXTR rs53576 has been associated with both prosocial and maladaptive behaviors but few studies have taken account of environmental factors. The present study determined whether the association of childhood maltreatment with conduct problems was modified by OXTR rs53576 genotypes. In a general population sample of 1591 teenagers, conduct problems as well as maltreatment were measured by self-report. DNA was extracted from saliva samples. In males, there was a significant positive association between maltreatment and conduct problems independent of the genotype. In females, among G allele carriers, the level of conduct problems was significantly higher among those who had been maltreated as compared to those not maltreated. By contrast, among female AA carriers, conduct problems did not vary between those who were, and who were not, maltreated. The results indicate that OXTR rs53576 plays a role in antisocial behavior in females such that the G allele confers vulnerability for antisocial behavior if they experience maltreatment, whereas the A allele has a protective effect.

Place, publisher, year, edition, pages
2018. Vol. 12, article id 112
Keywords [en]
conduct problems, gene–environment interaction, maltreatment, oxytocin receptor gene, rs53576
National Category
Neurosciences
Identifiers
URN: urn:nbn:se:uu:diva-368638DOI: 10.3389/fnhum.2018.00112ISI: 000428080100001PubMedID: 29623035OAI: oai:DiVA.org:uu-368638DiVA, id: diva2:1268502
Funder
Forte, Swedish Research Council for Health, Working Life and Welfare, 2015-00897Åke Wiberg Foundation, M15-0239Swedish Research Council, VR: 2015-00495Fredrik och Ingrid Thurings StiftelseEU, FP7, Seventh Framework Programme, INCA 600398Available from: 2018-12-06 Created: 2018-12-06 Last updated: 2019-06-28Bibliographically approved

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Comasco, ErikaÅslund, CeciliaNilsson, Kent W.
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