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Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits.
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2018 (English)In: Nature Genetics, ISSN 1061-4036, E-ISSN 1546-1718, Vol. 50, no 10, p. 1412-1425Article in journal (Refereed) Published
Abstract [en]

High blood pressure is a highly heritable and modifiable risk factor for cardiovascular disease. We report the largest genetic association study of blood pressure traits (systolic, diastolic and pulse pressure) to date in over 1 million people of European ancestry. We identify 535 novel blood pressure loci that not only offer new biological insights into blood pressure regulation but also highlight shared genetic architecture between blood pressure and lifestyle exposures. Our findings identify new biological pathways for blood pressure regulation with potential for improved cardiovascular disease prevention in the future.

Place, publisher, year, edition, pages
2018. Vol. 50, no 10, p. 1412-1425
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Medical Genetics
Identifiers
URN: urn:nbn:se:uu:diva-367084DOI: 10.1038/s41588-018-0205-xISI: 000446047000013PubMedID: 30224653OAI: oai:DiVA.org:uu-367084DiVA, id: diva2:1266405
Funder
EU, European Research CouncilNovo Nordisk, NNF15CC0018486EU, FP7, Seventh Framework Programme, HEALTH-F2-2013-601456Wellcome trust, RE/13/1/30181Wellcome trust, WT098051Available from: 2018-11-28 Created: 2018-11-28 Last updated: 2018-12-05Bibliographically approved

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Enroth, StefanGiedraitis, VilmantasGyllensten, Ulf B.Ingelsson, ErikJohansson, ÅsaLind, LarsSundström, Johan
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Science for Life Laboratory, SciLifeLabDepartment of Immunology, Genetics and PathologyGeriatricsMolecular epidemiologyCardiovascular epidemiology
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