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How is cardiac troponin released from injured myocardium?
Med Univ Innsbruck, Heart Ctr, Dept Internal Med Cardiol & Angiol 3, Innsbruck, Austria.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Cardiology. Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm, UCR-Uppsala Clinical Research Center.ORCID iD: 0000-0002-5795-0061
Univ Gothenburg, Dept Clin Chem & Transfus Med, Gothenburg, Sweden.
Univ Hosp Basel, Dept Cardiol, Basel, Switzerland; Univ Hosp Basel, Cardiovasc Res Inst Basel, Basel, Switzerland.
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2018 (English)In: European heart journal. Acute cardiovascular care., ISSN 2048-8726, Vol. 7, no 6, p. 553-560Article in journal (Refereed) Published
Abstract [en]

Cardiac troponin I and cardiac troponin T are nowadays the criterion biomarkers for the laboratory diagnosis of acute myocardial infarction due to their very high sensitivities and specificities for myocardial injury. However, still many aspects of their degradation, tissue release and elimination from the human circulation are incompletely understood. Myocardial injury may be caused by a variety of different mechanisms, for example, myocardial ischaemia, inflammatory and immunological processes, trauma, drugs and toxins, and myocardial necrosis is preceded by a substantial reversible prelethal phase. Recent experimental data in a pig model of myocardial ischaemia demonstrated cardiac troponin release into the circulation from apoptotic cardiomyocytes as an alternative explanation for clinical situations with increased cardiac troponin without any other evidence for myocardial necrosis. However, the comparably lower sensitivities of all currently available imaging modalities, including cardiac magnetic resonance imaging for the detection of particularly non-focal myocardial necrosis in patients, has to be considered for cardiac troponin test result interpretation in clinical settings without any other evidence for myocardial necrosis apart from increased cardiac troponin concentrations as well.

Place, publisher, year, edition, pages
SAGE PUBLICATIONS LTD , 2018. Vol. 7, no 6, p. 553-560
Keywords [en]
Cardiac troponin I, cardiac troponin T, myocardial injury, release, reversible, necrosis, apoptosis
National Category
Cardiac and Cardiovascular Systems
Identifiers
URN: urn:nbn:se:uu:diva-366275DOI: 10.1177/2048872617748553ISI: 000444973300008PubMedID: 29278915OAI: oai:DiVA.org:uu-366275DiVA, id: diva2:1265739
Available from: 2018-11-26 Created: 2018-11-26 Last updated: 2018-11-26Bibliographically approved

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