Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Genome-wide association study of coronary artery disease among individuals with diabetes: the UK Biobank
Uppsala University, Science for Life Laboratory, SciLifeLab. Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Molecular epidemiology.ORCID iD: 0000-0003-2071-5866
Uppsala University, Science for Life Laboratory, SciLifeLab. Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Molecular epidemiology.ORCID iD: 0000-0001-5894-0351
Lund Univ, Dept Clin Sci Malmo, Malmo, Sweden.
Uppsala University, Science for Life Laboratory, SciLifeLab. Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Molecular epidemiology. Stanford Univ, Dept Med, Div Cardiovasc Med, Stanford, CA USA;Stanford Univ, Stanford Cardiovasc Inst, Stanford, CA USA.ORCID iD: 0000-0003-2256-6972
2018 (English)In: Diabetologia, ISSN 0012-186X, E-ISSN 1432-0428, Vol. 61, no 10, p. 2174-2179Article in journal (Refereed) Published
Abstract [en]

Coronary artery disease (CAD) is a common complication among individuals with diabetes. A better understanding of the genetic background of CAD in this population has the potential to suggest novel molecular targets for screening, risk assessment and drug development. We performed a genome-wide association study of CAD in 15,666 unrelated individuals (3,968 CAD cases and 11,698 controls) of white British ancestry with diabetes at inclusion in the UK Biobank study. Our results were compared with results from participants without diabetes. We found genome-wide significant evidence for association with CAD at the previously well-established LPA locus (lead variant: rs74617384; OR 1.38 [95% CI 1.26, 1.51], p = 3.2 x 10(-12)) and at 9p21 (lead variant: rs10811652; OR 1.19 [95% CI 1.13, 1.26], p = 6.0 x 10(-11)). Moreover, other variants previously associated with CAD showed similar effects in the participants with and without diabetes, indicating that the genetic architecture of CAD is largely the same. Our results indicate large similarities between the genetic architecture of CAD in participants with and without diabetes. Larger studies are needed to establish whether there are important diabetes-specific CAD loci.

Place, publisher, year, edition, pages
2018. Vol. 61, no 10, p. 2174-2179
Keywords [en]
Diabetes, Genetic epidemiology, Ischaemic heart disease, UK Biobank
National Category
Endocrinology and Diabetes
Identifiers
URN: urn:nbn:se:uu:diva-364162DOI: 10.1007/s00125-018-4686-zISI: 000443448100012PubMedID: 30003307OAI: oai:DiVA.org:uu-364162DiVA, id: diva2:1261343
Funder
Swedish Research Council, 2015-03477Swedish Heart Lung Foundation, 20150429Göran Gustafsson Foundation for Research in Natural Sciences and Medicine, 1637NIH (National Institute of Health), R01DK106236Available from: 2018-11-07 Created: 2018-11-07 Last updated: 2018-11-16Bibliographically approved

Open Access in DiVA

fulltext(1009 kB)54 downloads
File information
File name FULLTEXT02.pdfFile size 1009 kBChecksum SHA-512
396fe735506b9b65de3170b37c35c13920f92814026723a58f90141723f8c5e2c16bb1ea69ba78eada00760abf0a3b5afaa2cc2957557ad4a17a9a8bd0d5fab0
Type fulltextMimetype application/pdf

Other links

Publisher's full textPubMed

Search in DiVA

By author/editor
Fall, ToveGustafsson, StefanIngelsson, Erik
By organisation
Science for Life Laboratory, SciLifeLabMolecular epidemiology
In the same journal
Diabetologia
Endocrinology and Diabetes

Search outside of DiVA

GoogleGoogle Scholar
Total: 54 downloads
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

doi
pubmed
urn-nbn

Altmetric score

doi
pubmed
urn-nbn
Total: 66 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf